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首页> 外文期刊>Applied Surface Science >Ultrasmall Gd_2O_3 nanoparticles surface-coated by polyacrylic acid (PAA) and their PAA-size dependent relaxometric properties
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Ultrasmall Gd_2O_3 nanoparticles surface-coated by polyacrylic acid (PAA) and their PAA-size dependent relaxometric properties

机译：聚丙烯酸（PAA）表面包覆的超小Gd_2O_3纳米粒子及其依赖于PAA尺寸的弛豫特性

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摘要

Ultrasmall Gd2O3 nanoparticles can potentially be used as a positive magnetic resonance imaging (MRI) contrast agent owing to their high content of Gd(III), which exhibits the highest spin magnetic moment of all elements due to its seven unpaired 4f electrons. Herein, the above nanoparticles (average diameter = 2.0 nm) were coated with hydrophilic biocompatible polyacrylic acids (PAAs) of different molecular weights (M-w = 1200, 5100, 15000 Da), and the PAA-size-dependent relaxometric properties of the thus obtained composites were investigated. In addition, the biocompatibility of these composites was assessed by in-vitro cell viability measurements. Finally, dose-dependent R-1 map images were acquired, proving that PAA-coated nanoparticles can be used as a T-1 MRI contrast agent. (C) 2017 Elsevier B.V. All rights reserved.
机译：由于Gd（III）含量高，因此超小Gd2O3纳米颗粒可潜在地用作正磁共振成像（MRI）造影剂，由于其七个不成对的4f电子，Gd（III）表现出所有元素的最高自旋磁矩。在此，上述纳米颗粒（平均直径＝ 2.0nm）被不同分子量（Mw ＝ 1200、5100、15000Da）的亲水性生物相容性聚丙烯酸（PAA）包覆，由此获得了PAA尺寸依赖性的弛豫特性。复合材料进行了调查。另外，这些复合物的生物相容性通过体外细胞活力测量来评估。最后，获得了剂量依赖性的R-1图图像，证明PAA涂层的纳米颗粒可以用作T-1 MRI造影剂。 （C）2017 Elsevier B.V.保留所有权利。

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  • 来源
    《Applied Surface Science》 |2019年第31期|111-115|共5页
  • 作者

    Miao Xu; Xu Wenlong; Cha Hyunsil; Chang Yongmin; Oh In Taek; Chae Kwon Seok; Tegafaw Tirusew; Ho Son Long; Kim Sung June; Lee Gang Ho;

  • 作者单位

    KNU, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea|KNU, Coll Nat Sci, DNN, Taegu 41566, South Korea;

    KNU, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea|KNU, Coll Nat Sci, DNN, Taegu 41566, South Korea;

    KNU & Hosp, Sch Med, Dept Mol Med & Med & Biol Engn, Taegu 41566, South Korea|KNU & Hosp, Sch Med, DNN, Taegu 41566, South Korea;

    KNU & Hosp, Sch Med, Dept Mol Med & Med & Biol Engn, Taegu 41566, South Korea|KNU & Hosp, Sch Med, DNN, Taegu 41566, South Korea;

    KNU, Teachers Coll, Dept Biol Educ, Taegu 41566, South Korea|KNU, Teachers Coll, DNN, Taegu 41566, South Korea;

    KNU, Teachers Coll, Dept Biol Educ, Taegu 41566, South Korea|KNU, Teachers Coll, DNN, Taegu 41566, South Korea;

    KNU, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea|KNU, Coll Nat Sci, DNN, Taegu 41566, South Korea;

    KNU, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea|KNU, Coll Nat Sci, DNN, Taegu 41566, South Korea;

    KNU, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea|KNU, Coll Nat Sci, DNN, Taegu 41566, South Korea;

    KNU, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea|KNU, Coll Nat Sci, DNN, Taegu 41566, South Korea;

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  • 正文语种 eng
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  • 关键词

    Ultrasmall Gd2O3 nanoparticle; PAA surface coating; PAA size effect; Relaxometric property; Biocompatibility;

    机译：Gd2O3超小纳米颗粒;PAA表面涂层;PAA尺寸效应;相对计量性能;生物相容性;

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