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首页> 外文期刊>Aquatic Sciences >Resistance to oxidative stress is not associated with the exceptional longevity of the freshwater pearl mussel, Margaritifera margaritifera nor three unionid species
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Resistance to oxidative stress is not associated with the exceptional longevity of the freshwater pearl mussel, Margaritifera margaritifera nor three unionid species

机译：抵抗氧化应激与淡水珍珠贻贝，玛格丽塔玛格丽塔芙拉或三种混种物种的超长寿命无关

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摘要

Bivalve molluscs are newly discovered models of successful ageing. Here, we test the hypothesis that extreme longevity of freshwater mussels is associated with an enhanced resistance to oxidative stress. We assess whether resistance to oxidative stress might be causally involved in the exceptional longevity exhibited by the freshwater pearl mussel Margaritifera margaritifera. We compared resistance to oxidative stress and total haemocyte counts, a health status biomarker in M. margaritifera (maximum lifespan potential 190 years) with three other freshwater bivalve species spanning a range of longevities. Previous studies of the comparative stress resistance and longevity of marine bivalves provide evidence for the hypothesis that an association exists between longevity and not only an enhanced resistance to oxidative stress but also a general resistance to multiplex stressors. We compared baseline total haemocyte counts, age-related changes, and responses to exposure to the oxidative stressor tert-butyl hydroperoxide (TBHP). Surprisingly our data does not support the premise that extreme longevity in M. margaritifera is associated with enhanced resistance to oxidative stress. In comparison with its shorter-lived counter parts M. margaritifera was the least resistance to oxidative stress. Following TBHP exposure, no association between longevity and resistance to oxidative stress-induced mortality nor a marked resistance to oxidative stress-induced declines in total haemocyte counts were observed. The results suggest longevity evolved separately in freshwater mussels and this group warrants further attention from bi-ogerontologists because such study may provide novel insights not detected through the study of the marine members of the class, where most attention is currently focused.
机译：双壳类软体动物是新发现的成功衰老模型。在这里，我们检验了如下假设：淡水贻贝的超长寿命与增强的抗氧化应激能力有关。我们评估对淡水珍珠贻贝玛格丽塔酒玛格丽塔酒表现出的超长寿命是否可能因抗氧化压力而引起。我们将抗氧化应激和总血红细胞计数（玛格丽特杆菌的健康状况生物标记物（最大寿命潜力为190年））与其他三个跨度长寿的淡水双壳类进行了比较。先前对海洋双壳类动物的比较抗性和寿命的研究为以下假设提供了证据：寿命与不仅对氧化应激的增强抵抗力，而且对多重应激源的一般抵抗力之间存在联系。我们比较了基线总血细胞计数，与年龄有关的变化以及对暴露于氧化应激性叔丁基氢过氧化物（TBHP）的反应。令人惊讶的是，我们的数据不支持玛格丽特果的超长寿命与增强的抗氧化应激能力有关的前提。与它的相对较短的对立部分相比，玛格丽特酵母对氧化应激的抵抗力最小。接触TBHP后，未观察到长寿与对氧化应激诱导的死亡率的抵抗力之间的关联，也未观察到对氧化应激诱导的总血红细胞计数下降的明显抵抗。结果表明，长寿在淡水贻贝中单独发展，这一群体值得进一步研究，因为这种研究可能会提供目前通过该类别的海洋成员进行研究而无法发现的新颖见解，因此该研究可能会提供更多新的见识。

著录项

  • 来源
    《Aquatic Sciences》 |2014年第2期|259-267|共9页
  • 作者

    Iain Ridgway; T. J. Bowden; A. Roman-Gonzalez; C. A. Richardson;

  • 作者单位

    School of Ocean Sciences, College of Natural Sciences, Bangor University, Anglesey LL59 5AB, UK,Max Planck Institute for Demographic Research, 1 Konrad-Zuse Strasse, 18057 Rostock, Germany;

    Aquaculture Research Institute, School of Food and Agriculture, University of Maine, Orono, ME 04469-5735, USA;

    School of Ocean Sciences, College of Natural Sciences, Bangor University, Anglesey LL59 5AB, UK;

    School of Ocean Sciences, College of Natural Sciences, Bangor University, Anglesey LL59 5AB, UK;

  • 收录信息 美国《科学引文索引》(SCI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Margaritifera margaritifera; Ageing; Oxidation; Longevity; Stress resistance;

    机译：玛格丽特（Margaritifera）老化;氧化;长寿;抗压力;

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