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首页> 外文期刊>Aquatic Sciences >Photodegradation of the Pharmaceuticals atorvastatin, carbamazepine, levofloxacin, and sulfamethoxazole in natural waters
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Photodegradation of the Pharmaceuticals atorvastatin, carbamazepine, levofloxacin, and sulfamethoxazole in natural waters

机译：天然水中阿托伐他汀，卡马西平，左氧氟沙星和磺胺甲恶唑的光降解

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摘要

The photochemical behaviour of the four Pharmaceuticals, atorvastatin, carbamazepine, levofloxacin, and sulfamethoxazole in sunlit surface water was investigated. These compounds, which have been observed or have the potential to be in surface waters, were susceptible to direct and indirect photodegradation. Several photoproducts are identified using authentic standards, and structures of other degradation products are proposed based on mass spectral information from this and previous studies. The same degradation compounds are formed from direct and indirect photolysis, suggesting the same photoproducts are formed by alternate pathways. The natural water constituents nitrate, dissolved organic matter (DOM), and bicarbonate influence the elimination rates of the pharmaceuticals differently. Since direct photolysis appears important in limiting the persistence of levofloxacin and sulfamethoxazole, the presence of humic matter decreases degradation rates. The same constituent has an opposite and positive effect on the elimination rates of atorvastatin and carbamazepine and thus, photosensitization reactions or photooxidants generated from DOM photolysis are important. Products resulting from direct and indirect photolysis also seem to be susceptible to photodegradation, suggesting they will not persist in sunlit aqueous systems.
机译：研究了四种药物阿托伐他汀，卡马西平，左氧氟沙星和磺胺甲恶唑在阳光下的地表水中的光化学行为。这些化合物已经被观察到或可能存在于地表水中，因此容易受到直接和间接的光降解。使用可靠的标准品可以鉴定出几种光产物，并根据本次研究和以前的研究中的质谱信息提出了其他降解产物的结构。相同的降解化合物是通过直接和间接的光解作用形成的，这表明相同的光产物是通过交替途径形成的。天然水中的硝酸盐，溶解性有机物（DOM）和碳酸氢盐对药物清除率的影响不同。由于直接光解对限制左氧氟沙星和磺胺甲恶唑的持久性显得很重要，因此腐殖质的存在会降低降解速率。相同的成分对阿托伐他汀和卡马西平的消除速率具有相反和正面的影响，因此，由DOM光解产生的光敏反应或光氧化剂很重要。直接和间接光解产生的产物似乎也易于光降解，表明它们不会在阳光照射的水性体系中持久存在。

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