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首页> 外文期刊>Arabian Journal for Science and Engineering >In Vitro Antimicrobial Activity and GC-MS Findings of the Gel of Aloe vacillans Forssk. of Abha Region, Saudi Arabia
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In Vitro Antimicrobial Activity and GC-MS Findings of the Gel of Aloe vacillans Forssk. of Abha Region, Saudi Arabia

机译：芦荟福尔斯克凝胶的体外抗菌活性和GC-MS结果。沙特阿拉伯艾卜哈地区的地图

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摘要

A great variety of weeds grow in the Abha area, Saudi Arabia, at more than 2700 m above sea level. The aim of this study was to evaluate the antimicrobial activities of various extracts of fresh and dry leaf gel of Aloe vacillans against eight clinical isolates of human pathogens. The chemical compounds present in the gel extract were identified and quantified by gas chromatography-mass spectrometry. Solvent extracts inhibited 62.5% of the examined microbes, whereas the fresh leaf extract was more potent and active against Staphylococcus aureus, Micrococcus luteus, Klebsiella oxytocam, Proteus mirabilis, and Candida albicans compared to the dry leaf extract. No antimicrobial activities were observed against Klebsiella pneumonia, Shigella flexneri, and Pseudomonas aeruginosa. Candida albicans was the most susceptible pathogen based on its zone of inhibition. The maximum inhibitory activities were shown by the fresh gel of the chloroform extract against M. luteus, the methanol extract against S. aureus, the petroleum ether extract against P. mirabilis, C. albicans, and K. pneumoniae, and hot water extracts against K. oxytocam. Gram-positive bacteria and C. albicans were more susceptible than gram-negative bacteria. Compounds were identified and quantified; the major constituents of the gel were 1,3-dimethoxy-2-propanol and glycerol. Acetoglycerides, ethanol, 5-(hydroxymethyl)-2-furaldehyde, palmitic acid, butane, 1,2:3,4-diepoxy-,(..)-, 2-deoxy-d-galactose, butyl acetate, 2,2-dimethoxyethanol, diethyl phthalate, phytol, octadecanoic acid, gamma-linolenic acid, and stearic acid were present in low amounts. Therefore, because of its antimicrobial activities and useful phytochemical composition, A. vacillans leaf gel is a promising pharmaceutical drug for specific microbial infections and for improving health.
机译：在海拔2700 m以上的沙特阿拉伯艾卜哈地区，杂草繁多。这项研究的目的是评估芦荟新鲜和干叶凝胶的各种提取物对八种人类病原体临床分离株的抗菌活性。通过气相色谱-质谱法鉴定和定量凝胶提取物中存在的化合物。与干叶提取物相比，溶剂提取物抑制了所检查微生物的62.5％，而新鲜叶提取物对金黄色葡萄球菌，黄球微球菌，产氧克雷伯菌，变形杆菌和白色念珠菌的效力和活性更高。没有观察到针对肺炎克雷伯菌，弗氏志贺氏菌和铜绿假单胞菌的抗菌活性。根据其抑制区域，白色念珠菌是最易感的病原体。最大的抑制活性通过氯仿提取物对黄褐腐霉菌，甲醇提取物对金黄色葡萄球菌，石油醚提取物对P. mirabilis，白色念珠菌和肺炎克雷伯菌和热水提取物的新鲜凝胶表现出。催产素K.革兰氏阳性细菌和白色念珠菌比革兰氏阴性细菌更易感。对化合物进行鉴定和定量；凝胶的主要成分是1,3-二甲氧基-2-丙醇和甘油。乙酰甘油酯，乙醇，5-（羟甲基）-2-呋喃醛，棕榈酸，丁烷，1,2：3,4-二环氧-（（..）-，2-脱氧-d-半乳糖，乙酸丁酯，2,2 -二甲氧基乙醇，邻苯二甲酸二乙酯，植醇，十八烷酸，γ-亚麻酸和硬脂酸的含量低。因此，由于其抗菌活性和有用的植物化学组成，A。vacillans叶凝胶是用于特定微生物感染和改善健康的有前途的药物。

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