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首页> 外文期刊>Arabian Journal for Science and Engineering >SURFACTANT ENHANCED REACTION BETWEEN BENZOCAINE AND PDIMETHYLAMINOBENZALDEHYDE: KINETIC STUDY AND ITS ANALYTICAL APPLICATION
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SURFACTANT ENHANCED REACTION BETWEEN BENZOCAINE AND PDIMETHYLAMINOBENZALDEHYDE: KINETIC STUDY AND ITS ANALYTICAL APPLICATION

机译：苯佐卡因与二甲基氨基苯甲酸二乙醛之间的表面活性剂增强反应：动力学研究及其分析应用

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摘要

Benzocaine is well known as an insoluble substrate in water. Therefore, its physical and analytical treatments in the presence of surfactant may allow organic solvents to be replaced by aqueous surfactants solutions. The effect of the presence of anionic surfactant (sodium dodecyl sulfate, SDS) upon the condensation reaction of benzocaine with water insoluble p-dimethylaminobenzaldehyde (DAB) in aqueous solution has been investigated extensively. The presence of 5 × 10~(-3)M SDS increases the reaction rate by 20 times in contrast to that of a solution in 20% ethanol. A substantial increase in absorption band due to the formed Schiff base followed by a red shift has been observed. A great advantage in analytical application resulting from the presence of surfactant due to the formation of a charge transfer complex has been reported. The latter phenomenon has been realized and proved in this study, which depends merely on the charge of micelle surface. A simple, accurate, and sensitive method for microdetermination of benzocaine in aqueous surfactant solution has been introduced. The proposed procedure for analysis of the presented drug in its bulk form and pharmaceutical formulations is more sensitive and accurate than that of the British pharmacopoeia method. It has been concluded that the replacing of organic co-solvents by surfactants was not only captured for avoiding their pollution and toxic implication but there are some advantages gained from the presence of surfactant molecules. The used surfactant compound (SDS) in this study is quite green and is commonly used as a detergent in toothpaste.
机译：众所周知，苯佐卡因是水中的不溶性底物。因此，其在表面活性剂存在下的物理和分析处理可以使有机溶剂被表面活性剂水溶液代替。阴离子表面活性剂（十二烷基硫酸钠，SDS）的存在对苯佐卡因与水不溶性对二甲基氨基苯甲醛（DAB）在水溶液中缩合反应的影响已得到广泛研究。与在20％乙醇中的溶液相比，5×10〜（-3）M SDS的存在将反应速率提高了20倍。观察到由于形成的席夫碱使吸收带显着增加，随后出现红移。据报道，由于电荷转移络合物的形成，由于存在表面活性剂，在分析应用中具有很大优势。后一种现象已在本研究中实现并得到证明，该现象仅取决于胶束表面的电荷。引入了一种简单，准确和灵敏的方法测定表面活性剂水溶液中的苯佐卡因。拟议的用于分析呈递形式和药物配方的药物的程序比英国药典方法更灵敏，更准确。已经得出结论，捕获表面活性剂代替有机助溶剂不仅是为了避免其污染和毒性影响，而且由于存在表面活性剂分子而具有一些优点。本研究中使用的表面活性剂化合物（SDS）非常绿色，通常用作牙膏中的清洁剂。

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