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首页> 外文期刊>Arabian Journal for Science and Engineering >Antimicrobial Activity and GC-MS Analysis of Bioactive Constituents of Thermophilic Bacteria Isolated from Saudi Hot Springs
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Antimicrobial Activity and GC-MS Analysis of Bioactive Constituents of Thermophilic Bacteria Isolated from Saudi Hot Springs

机译：沙特温泉中嗜热细菌生物活性成分的抗菌活性和GC-MS分析

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摘要

The bioactivity of thermophilic bacteria isolated from hot springs in the southern region of Saudi Arabia was investigated. Of the 84 bacterial isolates, the antimicrobial activity of 50 of them had an antagonistic effect against one or more of the tested human pathogens: Candida albican, Staphylococcus aureus, Proteus mirabilis, Klebsiella pneumonia and Shigella flexneri. Furthermore, four isolates exhibited the highest antagonistic ability against all pathogens. The molecular identification of selected promising isolates and phylogenetic analysis confirmed the accurate identity of the isolates as Bacillus sonorensis, Bacillus thermocopriae, Brevibacillus borstelensis and Brevibacillus parabrevis. GC-MS analysis of the cell-free extracts detected 40 secondary metabolites; each strain has its own secondary metabolites in addition to other compounds that are of industrial and pharmaceutical importance. The major secondary metabolites produced were cyclohexyl acrylate, imiloxan, tabtoxinine-beta-lactam, nicotinyl alcohol, mephenesin, etomidate, L-menthyl lactate, (3-aminopropyl) dibutylborane, filbertone, and 1-dotriacontanol. These findings suggest a need to raise awareness of the value hot springs in Saudi Arabia have as locations for isolating thermophilic bacteria that could possibly serve as reservoirs for new bioactive compounds of industrial and medical importance.
机译：研究人员从沙特阿拉伯南部地区的温泉中分离出嗜热细菌的生物活性。在这84种细菌分离物中，其中50种具有抗微生物活性，对一种或多种测试的人类病原体具有拮抗作用：白色念珠菌，金黄色葡萄球菌，变形杆菌，肺炎克雷伯菌和弗氏志贺氏菌。此外，四种分离物表现出对所有病原体的最高拮抗能力。选定的有前途的分离物的分子鉴定和系统发育分析证实了这些分离物的准确身份，如芽孢杆菌，嗜热芽孢杆菌，波氏短杆菌和副短杆菌。无细胞提取物的GC-MS分析检测到40种次级代谢产物；除了具有工业和药学重要性的其他化合物外，每个菌株还具有其自身的次级代谢产物。产生的主要次要代谢产物是丙烯酸环己酯，亚氨基氧杂环丁烷，甲氧新霉素-β-内酰胺，烟碱醇，甲芬素，依托咪酯，乳酸L-薄荷基酯，（3-氨基丙基）二丁基硼烷，西伯酮和1-dotriacontanol。这些发现表明，有必要提高人们对沙特阿拉伯温泉作为隔离嗜热细菌的场所的价值的认识，这些嗜热细菌可能充当具有工业和医学重要性的新型生物活性化合物的储存库。

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  • 来源
    《Arabian Journal for Science and Engineering》 |2019年第1期|75-85|共11页
  • 作者

    Alrumman S. A.; Mostafa Y. S.; Al-Qahtani Shekha T. S.; Sahlabji T.; Taha T. H.;

  • 作者单位

    King Khalid Univ, Coll Sci, Dept Biol, POB 9004, Abha 61413, Saudi Arabia;

    King Khalid Univ, Coll Sci, Dept Biol, POB 9004, Abha 61413, Saudi Arabia;

    King Khalid Univ, Coll Sci, Dept Biol, POB 9004, Abha 61413, Saudi Arabia|Univ Bisha, Coll Sci, Dept Biol, POB 551, Bisha 61922, Saudi Arabia;

    King Khalid Univ, Dept Chem, Coll Sci, POB 9004, Abha 61413, Saudi Arabia;

    City Sci Res & Technol Applicat, Genet Engn & Biotechnol Res Inst, Environm Biotechnol Dept, POB 21934, Alexandria, Egypt;

  • 收录信息 美国《科学引文索引》(SCI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Hot springs; Thermophilic bacteria; Antagonism; Bioactivity;

    机译：温泉;嗜热细菌;拮抗作用;生物活性;

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