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首页> 外文期刊>Arabian Journal for Science and Engineering >Chemical Fingerprinting, Anticancer, Anti-inflammatory and Free Radical Scavenging Properties of Calamintha fenzlii Vis. Volatile Oil from Palestine
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Chemical Fingerprinting, Anticancer, Anti-inflammatory and Free Radical Scavenging Properties of Calamintha fenzlii Vis. Volatile Oil from Palestine

机译：Calamintha fenzlii Vis的化学指纹图谱，抗癌，抗炎和自由基清除特性。

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摘要

Many phytochemicals have medicinal properties including anti-inflammatory, antioxidant and cytotoxic activities. The currentstudy aims to estimate and identify the chemical composition of Calamintha fenzlii Vis. leaves volatile oil and toevaluate its cytotoxic, anti-inflammatory and antioxidant properties. The volatile oil (VO) of C. fenzlii leaves was separatedusing microwave ultrasonic method and the chemical composition was characterized using Gas Chromatography–Mass Spectroscopymethod.The anti-inflammatory, antioxidant and cytotoxic activitieswere determined using aCOXinhibitor screening,the DPPH-free radical scavenging and MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-cyrboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt) cell viability colorimetric assays, respectively. The chemical constituents of C. fenzlii VO weredominated by oxygenated monoterpenoid (96.91%). The major chemical components of C. fenzlii VO were represented bymenthone 68.93% and pulegone 23.1%. The cytotoxicity test results revealed that the 23.22, 11.6, 5.8 and 2.9 mg/ml of C.fenzlii VO treatments induced cell death significantly (p ≤0.0001) by 70%, while 1.4 and 0.7 mg/ml induced cell cytotoxicitysignificantly (p ≤0.0001) by approximately 50% and 40%, respectively. The VO showed moderate antioxidant activitywith an IC_(50) value of 15.38±0.81 μg/ml. The COX-1 IC_(50) value was 0.215 μg/ml, while COX-2 IC_(50) was 0.241 μg/ml.Our data demonstrate for the first time that the VO of the Palestinian C. fenzlii plant possesses cytotoxic, anti-inflammatoryand antioxidants effects. It is a good source of therapeutic active compounds that could have potential applications in thenutraceutical and pharmaceutical industries.
机译：许多植物化学物质具有药用特性，包括抗炎，抗氧化剂和细胞毒活性。当前的研究旨在估计和鉴定Calamintha fenzlii Vis的化学成分。留下挥发油并评估其细胞毒性，抗炎和抗氧化特性。用微波超声法分离了犬樟叶的挥发油（VO），并用气相色谱-质谱法对其化学成分进行了表征。用COX抑制剂筛选，DPPH自由基清除和抗氧化作用测定了其抗炎，抗氧化和细胞毒性活性。 MTS（3-（4,5-二甲基噻唑-2-基）-5-（3-环氧基甲氧基苯基）-2-（4-磺基苯基）-2H-四唑鎓，内盐）细胞活力比色测定。费氏梭菌VO的化学成分以氧化单萜类化合物为主（96.91％）。盐酸薄荷脑的主要化学成分为薄荷酮68.93％和普勒热酮23.1％。细胞毒性测试结果表明，分别以23.22、11.6、5.8和2.9 mg / ml的费氏梭菌VO处理可显着诱导细胞死亡（p≤0.0001）70％，而1.4和0.7 mg / ml则显着诱导细胞死亡（p≤0.0001）。 ）分别减少约50％和40％。 VO显示出中等的抗氧化活性，IC_（50）值为15.38±0.81μg/ ml。 COX-1 IC_（50）值为0.215μg/ ml，而COX-2 IC_（50）值为0.241μg/ ml。我们的数据首次证明巴勒斯坦C. fenzlii植物的VO具有细胞毒，抗-炎症和抗氧化剂作用。它是治疗活性化合物的良好来源，可在营养保健和制药行业中潜在应用。

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