...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Environmental Contamination and Toxicology >Immunotoxicity of Explosives-Contaminated Soil Before and After Bioremediation
【24h】

Immunotoxicity of Explosives-Contaminated Soil Before and After Bioremediation

机译：生物修复前后爆炸物污染土壤的免疫毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Soils from the Yorktown Naval Base contaminated with trinitrotoluene (TNT) and other explosives were used to prepare eluates before and after bioremediation using microbial growth amendments in the presence (P1 eluates) or absence (P2 eluates) of exogenous white rot fungus. Effectiveness of bioremediation was examined by several immunotoxicity assays—viability/growth of lymphocytes, cytokine production, and expression of the interleukin-2 (IL-2) receptor—using human peripheral blood mononuclear cells exposed to the eluates. Although TNT concentrations decreased in both P1 and P2 eluates relative to untreated baseline soil (BL) eluates, a recovery in lymphocyte growth/viability and IL-2 secretion was seen with P2 but not P1 eluates relative to BL eluates. IL-2 receptor levels were higher in cells exposed to BL and P2 eluates than when exposed to P1 eluates. Interferon-γ, tumor necrosis factor-β, and IL-10 levels were highest in BL and P2 eluates and lowest in P1 eluates. Taken together, these results suggest that treatment of the soil with microbial growth amendments in the absence but not the presence of exogenous white rot fungi lead to partial bioremediation as assessed by lymphocyte functions.
机译：在存在（P1洗脱液）或不存在（P2洗脱液）外源白腐真菌的情况下，使用微生物生长改良剂，在约克敦镇海军基地被三硝基甲苯（TNT）和其他炸药污染的土壤用于制备生物修复前后的洗脱液。使用暴露于洗脱液的人外周血单核细胞，通过几种免疫毒性测定（淋巴细胞的活力/生长，细胞因子产生以及白介素2（IL-2）受体的表达）来检验生物修复的有效性。尽管P1和P2洗脱液中的TNT浓度均相对于未处理的基准土壤（BL）洗脱液有所降低，但相对于BL洗脱液，P2洗脱液的淋巴细胞生长/生存力和IL-2分泌有所恢复，而P1洗脱液则没有。暴露于BL和P2洗脱液的细胞中IL-2受体水平高于暴露于P1洗脱液的细胞。干扰素-γ，肿瘤坏死因子-β和IL-10水平在BL和P2洗脱液中最高，而在P1洗脱液中最低。综上所述，这些结果表明，在不存在外源白腐真菌但不存在外源的情况下，用微生物生长改良剂处理土壤会导致部分生物修复（如淋巴细胞功能所评估）。

著录项

  • 来源
  • 作者

    L. A. Beltz; D. R. Neira; C. A. Axtell; S. Iverson; W. Deaton; T. J. Waldschmidt; J. A. Bumpus; C. G. Johnston;

  • 作者单位

    Department of Biology University of Northern Iowa Cedar Falls Iowa 50614 USA;

    Department of Biology University of Northern Iowa Cedar Falls Iowa 50614 USA;

    Environmental Programs University of Northern Iowa Cedar Falls Iowa 50614 USA;

    Department of Biology University of Northern Iowa Cedar Falls Iowa 50614 USA;

    Department of Biology University of Northern Iowa Cedar Falls Iowa 50614 USA;

    Department of Pathology University of Iowa College of Medicine Iowa City Iowa 52242 USA;

    Environmental Programs University of Northern Iowa Cedar Falls Iowa 50614 USA;

    Mycotech Corporation Butte Montana USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号