• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Environmental Contamination and Toxicology >Organochlorines and 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) in Cancerous and Noncancerous Breast Tissue: Do the Data Support the Hypothesis That Oxidative DNA Damage Caused by Organochlorines Affects Breast Cancer?
【24h】

Organochlorines and 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) in Cancerous and Noncancerous Breast Tissue: Do the Data Support the Hypothesis That Oxidative DNA Damage Caused by Organochlorines Affects Breast Cancer?

机译：癌性和非癌性乳腺癌组织中的有机氯和8-Hydroxy-2'-Deoxyguanosine（8-OHdG）：数据是否支持由有机氯引起的氧化性DNA损伤影响乳腺癌的假说？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A study was conducted to test the hypothesis that oxidative DNA damage caused by exposure to organochlorines is an important risk factor in breast cancer. This is the first study that evaluates this hypothesis by measuring 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, polychlorinated biphenyl (PCB) congeners, and isomers of bis (4-chlorophenyl)-1,1,1-trichloroethane (DDT) and bis (4-chlorophenyl)-2,2,2-dichloroethane (DDE) in cancerous and noncancerous tissue. We measured these compounds in 44 primary tumors (cancerous) and 21 benign breast biopsy (noncancerous) tissues. Overall, no significant differences were observed in the level of the organochlorines between the tissues. The median concentration for 8-OHdG was 10.5 fmol/mg DNA (1.7/105 deoxyguanosine residues), and 8.5 fmol/mg DNA (1.4/105 deoxyguanosine residues) in cancerous and noncancerous tissue, respectively. These values are similar to background levels. No significant differences were observed in 8-OHdG levels in cancerous versus noncancerous tissue, and no correlation was demonstrated between the organochlorines and 8-OHdG. The data thus do not support the hypothesis that oxidative DNA damage caused by exposure to organochlorines is an important risk factor in breast cancer.
机译：进行了一项研究以检验以下假设：暴露于有机氯引起的氧化DNA损伤是乳腺癌的重要危险因素。这是第一个通过测量8-羟基-2'-脱氧鸟苷（8-OHdG），氧化DNA损伤的生物标志物，多氯联苯（PCB）同源物和双（4-氯苯基）-1异构体来评估这一假设的研究。癌和非癌组织中的1,1,1-三氯乙烷（DDT）和双（4-氯苯基）-2,2,2-二氯乙烷（DDE）。我们在44例原发性肿瘤（癌性）和21例良性乳腺活检（非癌性）组织中测量了这些化合物。总体而言，在组织之间的有机氯水平上没有观察到显着差异。在癌组织和非癌组织中，8-OHdG的中位浓度分别为10.5 fmol / mg DNA（1.7 / 105 脱氧鸟苷残基）和8.5 fmol / mg DNA（1.4 / 105 脱氧鸟苷残基）。这些值类似于背景水平。在癌性组织与非癌性组织中，未观察到8-OHdG水平的显着差异，并且有机氯与8-OHdG之间也没有相关性。因此，这些数据不支持以下假设：由于暴露于有机氯引起的氧化DNA损伤是乳腺癌的重要危险因素。

著录项

  • 来源
  • 作者

    M. J. Charles; M. J. Schell; E. Willman; H. B. Gross; Y. Lin; S. Sonnenberg; M. L. Graham;

  • 作者单位

    Department of Environmental Toxicology University of California Davis California USA;

    Department of Biostatistics School of Public Health and Lineberger Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA;

    Department of Environmental Toxicology University of California Davis California USA;

    Department of Environmental Toxicology University of California Davis California USA;

    Department of Biostatistics School of Public Health and Lineberger Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA;

    Department of Biostatistics School of Public Health and Lineberger Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA;

    Department of Hematology and Oncology School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号