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Application of Immunohistochemistry to Cytology

机译：免疫组织化学在细胞学中的应用

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CONTEXT: The uses of monoclonal antibodies via immunochemistry have been reported frequently within the literature using various methodologies with applications to cytology specimens. The direct application of immunochemistry to cytology may have a variety of pitfalls that the general pathologist familiar with its application to histology may be unaware of when applying it prospectively to patient specimens. OBJECTIVE: To review common pitfalls when applying immunochemistry to cytology specimens and to suggest approaches to the more common differential dilemmas that apply to a variety of cytology specimens that could be seen in a general pathology practice. DATA SOURCES: The authors' own experiences of applying immunochemistry to cytopathology specimens within an academic setting along with supportive data from the literature. CONCLUSIONS: Immunochemistry can be used to increase the predictability of a cytology diagnosis if care is taken with the cytology sample preparation methodology and there is judicious use of select monoclonal antibody panels to support a specific cytology diagnosis. Up-to-date evidence-based antibody databases should be used when selecting antibody panels.
机译：语境：在文献中，已通过各种方法广泛报道了通过免疫化学使用单克隆抗体的方法，并将其应用于细胞学标本。免疫化学在细胞学上的直接应用可能会遇到许多陷阱，而熟悉病理学在组织学上的应用的普通病理学家可能会不知道这些潜在的缺陷。目的：回顾将免疫化学应用于细胞学标本时的常见陷阱，并提出适用于在各种病理学实践中可以看到的适用于各种细胞学标本的更常见的鉴别难题的方法。数据来源：作者在学术环境中将免疫化学应用于细胞病理学标本的经验以及来自文献的支持性数据。结论：如果采取了细胞学样品制备方法，并且可以明智地使用选择的单克隆抗体组来支持特定的细胞学诊断，则可以使用免疫化学来提高细胞学诊断的可预测性。选择抗体组时，应使用最新的循证抗体数据库。

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    《Archives of Pathology & Laboratory Medicine》 |2008年第3期|p.373-382|共10页
  • 作者

    Larry J Fowler Whitney A Lachar;

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    Larry J. Fowler, MD, Whitney A. Lachar, MDAccepted for publication March 23, 2007.From the Department of Pathology, University of Texas Health Science Center at San Antonio.The authors have no relevant financial interest in the products or companies described in this article.Reprints: Larry J. Fowler, MD, Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, Mail Code #7750, San Antonio, TX 78229-3900 (e-mail: fowler@ uthscsa.edu).,;

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