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首页> 外文期刊>Archives of Pharmacal Research >Natural products as potential anticonvulsants: Caffeoylquinic acids
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Natural products as potential anticonvulsants: Caffeoylquinic acids

机译：天然产品作为潜在的抗惊厥药：咖啡酰奎尼酸

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Current anticonvulsant therapies are generally directed at symptomatic treatment by suppressing excitability within the brain. Consequently, they have adverse effects such as cognitive impairment, dependence, and abuse. The need for more effective and less toxic anticonvulsants has generated renewed interest in natural products for the treatment of convulsions. Caffeoylquinic acids (CQs) are naturally occurring phenolic acids that are distributed widely in plants. There has been increasing interest in the biological activities of CQs in diseases of the central nervous system. In this issue, Nugroho et al. give evidence for the anticonvulsive effect of a CQ-rich extract from Aster glehni Franchet et Sckmidt. They optimized the extract solvent conditions, resulting in high levels of CQs and peroxynitrite-scavenging activity. Then, they investigated the sedative and anticonvulsive effects in pentobarbital- and pentylenetetrazole-induced models in mice. The CQ-rich extract significantly inhibited tonic convulsions as assessed by onset time, tonic extent, and mortality. They suggested that the CQ-rich extract from A. glehni has potential for treating convulsions. This report provides preclinical data which may be used for the development of anticonvulsants from natural products.
机译：当前的抗惊厥疗法通常是通过抑制大脑内的兴奋性来进行对症治疗。因此，它们具有负面影响，例如认知障碍，依赖性和滥用。对更有效和毒性更低的抗惊厥药的需求引起了人们对天然产品治疗惊厥的新兴趣。咖啡酰奎尼酸（CQs）是天然存在的酚酸，广泛分布在植物中。人们对中枢神经系统疾病中CQ的生物活性越来越感兴趣。在本期中，Nugroho等人。提供证据证明紫苑提取物富含CQ的提取物具有抗惊厥作用。他们优化了提取物的溶剂条件，从而获得了高水平的CQ和清除过氧亚硝酸盐的活性。然后，他们研究了戊巴比妥和戊四氮诱导的小鼠模型中的镇静和抗惊厥作用。通过发作时间，进食程度和死亡率评估，富含CQ的提取物显着抑制了强直性抽搐。他们认为，来自A. glehni的富含CQ的提取物具有治疗惊厥的潜力。该报告提供了可用于从天然产物开发抗惊厥药的临床前数据。

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