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首页> 外文期刊>Archives of Toxicology >Expression of hepatic and ovarian cytochrome P450 during estrous cycle in rats
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Expression of hepatic and ovarian cytochrome P450 during estrous cycle in rats

机译：大鼠动情周期肝，卵巢细胞色素P450的表达

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It is known that gender differences in drug metabolism are largely attributed to changes in sex and growth hormones. Serum concentrations of estradiol, progesterone, prolactin, follicle-stimulating hormone, and luteinizing hormone change markedly during the human menstrual cycle and the rat estrous cycle. However, little information is available regarding the effects of the human menstrual cycle or the rat estrous cycle on expression and activity of cytochrome P450 (CYP) isoforms. The present study was carried out to determine the expression and activity of CYP-dependent drug-metabolizing enzymes in the liver and ovary during the estrous cycle. The expression and activity of microsomal CYP isoforms (CYP1A1, CYP1A2, CYP1B1, CYP2B1, CYP2C11, CYP2C12, CYP2E1, CYP3A1, CYP3A2, and CYP4A), cytochrome b5 and NADPH-dependent CYP reductase in the liver and ovary were measured in female rats in diestrus and proestrus. Our results indicated that hepatic and ovarian expression and activity of CYP isoforms, cytochrome b5, and NADPH-dependent CYP reductase were not different between diestrus and proestrus, although serum estradiol concentration and uterus weight were markedly increased in the proestrus phase. These results suggest that the cytochrome P450-dependent system is not sensitive to changes in the estrous cycle, and further studies are warranted to determine the effects of the estrous cycle on in vivo metabolism of xenobiotics.
机译：众所周知，药物代谢中的性别差异主要归因于性别和生长激素的变化。在人类月经周期和大鼠发情周期中，血清雌二醇，孕酮，催乳激素，促卵泡激素和促黄体生成素的浓度发生明显变化。但是，关于人类月经周期或大鼠发情周期对细胞色素P450（CYP）亚型表达和活性的影响的信息很少。本研究旨在确定发情周期中肝脏和卵巢中CYP依赖性药物代谢酶的表达和活性。 CYP 5 依赖于细胞色素b 5 的微粒体CYP亚型（CYP1A1，CYP1A2，CYP1B1，CYP2B1，CYP2C11，CYP2C12，CYP2E1，CYP3A1，CYP3A2和CYP4A的表达和活性）在雌性大鼠的雌二醇和前雌激素中测量雌激素和卵巢。我们的结果表明，虽然血清雌二醇浓度和子宫重量显着增加，但雌二醇和雌激素之间CYP亚型，细胞色素b 5 和NADPH依赖性CYP还原酶在肝脏和卵巢中的表达和活性没有差异。发情期。这些结果表明，细胞色素P450依赖性系统对发情周期的变化不敏感，因此有必要进行进一步的研究以确定发情周期对异种生物体内代谢的影响。

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