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首页> 外文期刊>Archives of Toxicology >Toxicity and carcinogenicity of furan in human diet
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Toxicity and carcinogenicity of furan in human diet

机译：呋喃对人类饮食的毒性和致癌性

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摘要

Furan is formed during commercial or domestic thermal treatment of food. The initial surveys of furan concentrations in heat-treated foods, published by European and US authorities, revealed the presence of relatively high furan levels in coffee, sauces, and soups. Importantly, furan is consistently found in commercial ready-to-eat baby foods. Furan induces hepatocellular tumors in rats and mice and bile duct tumors in rats with a high incidence. Epidemiological studies are not available. It is assumed that cis-2-butene-1,4-dial, the reactive metabolite of furan, is the causative agent leading to toxicity and carcinogenicity. Based on this data, furan is classified as a possible human carcinogen. The initial exposure estimates revealed a relatively small margin (~2,000) between human exposure and those furan doses, which induce liver tumors in experimental animals. As this may give rise for concern, in this review, the currently available toxicological and mechanistic data of furan are summarized and discussed with regard to its applicability in assessing the risk of furan in human diet.
机译：呋喃是在食品的商业或家庭热处理过程中形成的。欧美当局对加热食品中的呋喃浓度进行的初步调查显示，咖啡，调味料和汤中存在较高的呋喃水平。重要的是，呋喃一直存在于商业即食婴儿食品中。呋喃在大鼠和小鼠中诱发肝细胞肿瘤，在大鼠中诱发胆管肿瘤，发病率很高。没有流行病学研究。假定呋喃的活性代谢产物顺式-2-丁烯-1,4-二聚体是导致毒性和致癌性的病原体。根据此数据，呋喃被分类为可能的人类致癌物。最初的接触估计表明，人接触和呋喃剂量之间存在相对较小的差异（约2,000），在实验动物中会诱发肝脏肿瘤。由于可能引起关注，在本综述中，就呋喃在评估人类饮食中呋喃风险的适用性方面进行了总结和讨论，对呋喃的当前可用毒理学和机理数据进行了总结和讨论。

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