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首页> 外文期刊>Archives of Toxicology >Identification and distribution of mercury species in rat tissues following administration of thimerosal or methylmercury
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Identification and distribution of mercury species in rat tissues following administration of thimerosal or methylmercury

机译：硫柳汞或甲基汞给药后大鼠组织中汞种类的鉴定和分布

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Methylmercury (Met-Hg) is one the most toxic forms of Hg, with a considerable range of harmful effects on humans. Sodium ethyl mercury thiosalicylate, thimerosal (TM) is an ethylmercury (Et-Hg)-containing preservative that has been used in manufacturing vaccines in many countries. Whereas the behavior of Met-Hg in humans is relatively well known, that of ethylmercury (Et-Hg) is poorly understood. The present study describes the distribution of mercury as (-methyl, -ethyl and inorganic mercury) in rat tissues (brain, heart, kidney and liver) and blood following administration of TM or Met-Hg. Animals received one dose/day of Met-Hg or TM by gavage (0.5 mg Hg/kg). Blood samples were collected after 6, 12, 24, 48, 96 and 120 h of exposure. After 5 days, the animals were killed, and their tissues were collected. Total blood mercury (THg) levels were determined by ICP-MS, and methylmercury (Met-Hg), ethylmercury (Et-Hg) and inorganic mercury (Ino-Hg) levels were determined by speciation analysis with LC-ICP-MS. Mercury remains longer in the blood of rats treated with Met-Hg compared to that of TM-exposed rats. Moreover, after 48 h of the TM treatment, most of the Hg found in blood was inorganic. Of the total mercury found in the brain after TM exposure, 63% was in the form of Ino-Hg, with 13.5% as Et-Hg and 23.7% as Met-Hg. In general, mercury in tissues and blood following TM treatment was predominantly found as Ino-Hg, but a considerable amount of Et-Hg was also found in the liver and brain. Taken together, our data demonstrated that the toxicokinetics of TM is completely different from that of Met-Hg. Thus, Met-Hg is not an appropriate reference for assessing the risk from exposure to TM-derived Hg. It also adds new data for further studies in the evaluation of TM toxicity.
机译：甲基汞（Met-Hg）是最有毒的汞形式之一，对人体有相当大的有害影响。硫柳水杨酸钠汞硫柳汞（TM）是一种含乙基汞（Et-Hg）的防腐剂，已在许多国家用于生产疫苗。尽管Met-Hg在人类中的行为是众所周知的，但对乙基汞（Et-Hg）的行为知之甚少。本研究描述了施用TM或Met-Hg后汞在大鼠组织（大脑，心脏，肾脏和肝脏）和血液中的分布情况（-甲基汞，-乙基汞和无机汞）。通过管饲法（0.5 mg Hg / kg），动物每天接受一剂Met-Hg或TM。暴露6、12、24、48、96和120小时后收集血液样本。 5天后，杀死动物，并收集它们的组织。 ICP-MS测定血液中总汞（THg）含量，LC-ICP-MS通过形态分析测定甲基汞（Met-Hg），乙基汞（Et-Hg）和无机汞（Ino-Hg）含量。与暴露于TM的大鼠相比，用Met-Hg处理的大鼠血液中的汞保留时间更长。此外，在TM处理48小时后，血液中发现的大多数汞都是无机的。在TM暴露后大脑中发现的总汞中，有63％以Ino-Hg的形式存在，其中Et-Hg为13.5％，Met-Hg为23.7％。通常，TM处理后的组织和血液中的汞主要以Ino-Hg的形式存在，但在肝脏和大脑中也存在大量的Et-Hg。两者合计，我们的数据表明TM的毒代动力学与Met-Hg完全不同。因此，Met-Hg不是评估暴露于TM来源的Hg的风险的适当参考。它还为TM毒性评估中的进一步研究提供了新数据。

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