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首页> 外文期刊>Archives of Toxicology >β-Glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2
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β-Glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2

机译：从药用蘑菇姬松茸中提取的β-葡聚糖可防止苯并[a] py对人肝癌细胞HepG2的遗传毒性作用

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摘要

The mushroom Agaricus blazei is studied for its nutraceutical potential and as a medicinal supplement. The aim of the present study was to investigate the chemoprotective effect of β-glucan extracted from the mushroom A. blazei against DNA damage induced by benzo[a]pyrene (B[a]P), using the comet assay (genotoxicity) and micronucleus assay with cytokinesis block (mutagenicity) in a human hepatoma cell line (HepG2). To elucidate the possible β-glucan mechanism of action, desmutagenesis or bioantimutagenesis types, three treatment protocols were tested: simultaneous, pre-treatment, and presimultaneous. The results showed that β-glucan does not exert genotoxic or mutagenic effect, but that it does protect against DNA damage caused by B[a]P in every protocol tested. The data suggest that β-glucan acts through binding to B[a]P or the capture of free radicals produced during its activation. On the other hand, the pre-treatment results also suggest the possibility that β-glucan modulates cell metabolism.
机译：研究了姬松茸蘑菇的营养潜力和作为药用补品。本研究的目的是利用彗星试验（遗传毒性）和微核研究从蘑菇蘑菇中提取的β-葡聚糖对苯并[a] py（B [a] P）诱导的DNA损伤的化学保护作用。人肝癌细胞系（HepG2）中的胞质分裂阻滞（致突变性）检测。为了阐明可能的β-葡聚糖作用机制，去突变或生物抗突变的类型，测试了三种治疗方案：同时，预处理和同时进行。结果表明，β-葡聚糖不具有遗传毒性或诱变作用，但在每种测试方案中都可以防止B [a] P引起的DNA损伤。数据表明，β-葡聚糖通过结合B [a] P或捕获其激活过程中产生的自由基而发挥作用。另一方面，预处理结果也暗示了β-葡聚糖调节细胞代谢的可能性。

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