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首页> 外文期刊>Archives of Toxicology >Mechanisms of estrogen-induced effects in avian reproduction caused by transovarian application of a xenoestrogen, diethylstilbestrol
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Mechanisms of estrogen-induced effects in avian reproduction caused by transovarian application of a xenoestrogen, diethylstilbestrol

机译：雌激素诱导的雌激素诱导的异源雌二醇己烯雌酚经卵巢应用的机制

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摘要

To clarify breeding failure in avian species caused by the estrogenicity of chemicals, alterations in the reproductive systems of Japanese quail exposed in ovo to a xenoestrogen were investigated. An injection of diethylstilbestrol (DES) into the yolk before incubation decreased, after sexual maturation, egg-laying performance of female quails, which accompanied inducing abnormal development of the oviducts. All females treated with 50 ng DES/g of egg did not lay eggs, while 0.5–5 ng DES/g reduced egg weight and eggshell strength and thickness. In the uterus (shell gland), the mRNAs for calcium regulating factors, osteopontin and calbindin D28 K, were reduced dose-dependently by DES. Scanning electron microscopy showed that shell thinning was pronounced in the mammillary and cuticular layers of the eggshell, regions where osteopontin proteins are reportedly located. These indicate that transovarian exposure to xenoestrogens causes malformation and dysfunction of the oviducts, where calcium regulating molecules could play key roles in eggshell thinning.
机译：为了弄清由于化学物质的雌激素性导致的禽类繁殖失败，调查了在卵中暴露于异雌激素的日本鹌鹑生殖系统的变化。孵化前向蛋黄中注射己烯雌酚（DES）的能力在性成熟后减少了雌性鹌鹑的产卵性能，并伴随着输卵管异常发育。用50 ng DES / g鸡蛋处理的所有雌性均未产卵，而0.5–5 ng DES / g鸡蛋减少了蛋重，蛋壳强度和厚度。在子宫（壳腺）中，DES可以剂量依赖性地降低钙调节因子，骨桥蛋白和钙结合蛋白D28 K的mRNA。扫描电子显微镜显示，在蛋壳的乳腺和表皮层，据报道骨桥蛋白蛋白所在的区域，壳变薄明显。这些表明经卵巢接触异种雌激素会引起输卵管畸形和功能障碍，其中钙调节分子可能在蛋壳变薄中起关键作用。

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