Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules

Vendela Asp; Veronica Lindström; Jan A. Olsson; Ulrika Bergström; Ingvar Brandt

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Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules

机译：3-甲基磺酰基-DDE和结构相关分子在肾上腺皮质Y-1细胞中的细胞毒性和皮质酮生成的减少

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The persistent environmental pollutant 3-methylsulfonyl-DDE (3-MeSO₂-DDE) undergoes bioactivation by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of several animal species in vivo and causes decreased glucocorticoid production and cell death in the zona fasciculata. This study presents extended investigations of the cytotoxic and endocrine disrupting effects of 3-MeSO₂-DDE and some structurally related molecules in the mouse adrenocortical cell line Y-1. Both 3-MeSO₂-DDE and, to a lesser extent, 3,3′(bis)-MeSO₂-DDE decreased corticosterone production and produced CYP11B1-dependent cytotoxicity in Y-1 cells. Neither 2-MeSO₂-DDE nor p,p′-DDE had any significant effect on either cell viability or corticosterone production, indicating that the presence and position of the methylsulfonyl moiety of 3-MeSO₂-DDE is crucial for its biological activity. The adrenocortical toxicant o,p′-DDD decreased corticosterone production but was not cytotoxic in this cell line. None of the compounds altered Cyp11b1 gene expression, indicating that 3-MeSO₂-DDE inhibits CYP11B1 activity on the protein level.

机译：持久性环境污染物3-甲基磺酰基-DDE（3-MeSO _{2 -DDE）在体内几种动物的肾上腺皮质中被细胞色素P450 11B1（CYP11B1）进行生物激活，导致糖皮质激素生成和细胞减少fasciculata中的死亡。这项研究提供了3-MeSO _{2 -DDE及其在小鼠肾上腺皮质细胞系Y-1中某些结构相关分子的细胞毒性和内分泌干扰作用的扩展研究。 3-MeSO _{2 -DDE和3,3'（bis）-MeSO _{2 -DDE在较小程度上都降低了皮质酮的产生并产生了CYP11B1依赖性细胞毒性。 Y-1细胞。 2-MeSO _{2 -DDE和p，p'-DDE都不对细胞活力或皮质酮产生有任何显着影响，表明3-MeSO _{的甲基磺酰基部分的存在和位置2 -DDE对其生物活性至关重要。肾上腺皮质毒性o，p'-DDD降低了皮质酮的产生，但在该细胞系中没有细胞毒性。这些化合物均未改变Cyp11b1基因表达，表明3-MeSO _{2 -DDE在蛋白水平上抑制CYP11B1活性。}}}}}}}

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《Archives of Toxicology》 |2009年第4期|p.389-396|共8页
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Vendela Asp; Veronica Lindström; Jan A. Olsson; Ulrika Bergström; Ingvar Brandt;
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1. Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules. [J] . Asp V, Lindstrom V, Olsson JA, Archives of Toxicology . 2009,第4期

机译：3-甲基磺酰基-DDE和结构相关分子在肾上腺皮质Y-1细胞中的细胞毒性和皮质酮生成的减少。
2. Comparative CYP-dependent binding of the adrenocortical toxicants 3-methylsulfonyl-DDE and o,p'-DDD in Y-1 adrenal cells. [J] . Hermansson V, Asp V, Bergman A, Archives of Toxicology . 2007,第11期

机译：Y-1肾上腺细胞中肾上腺皮质毒性物质3-甲基磺酰基-DDE和o，p'-DDD的比较CYP依赖性结合。
3. Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells [J] . Bing Li, Takashi Baba, Kanako Miyabayashi, Endocrine journal . 2017,第3期

机译：Ad4结合蛋白/类固醇生成因子1在调节肾上腺皮质Y-1细胞中NADPH产生中的作用
4. STEP decrease of anthropogenic CO_2; Solar Thermal Electrochemical Production of energetic molecules, a different solar energy conversion process [C] . S. Licht, H. Wu, B. Wang, Electrochemistry and climate change. . 2011

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5. IgE anti-HIV-1 in serum of HIV-1 infected children inhibits HIV-1 production in vitro and IgE mediates cytotoxicity against lymphoma cells expressing HIV-1 and peripheral blood mononuclear cells from an HIV-1 seropositive patient [D] . Bluth, Martin Heath. 1997

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6. Adrenocortical control in the neonatal rat: ACTH- and cAMP-independent corticosterone production during hypoxia [O] . Karl Johnson, Eric D Bruder, Hershel Raff 2013

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7. Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells [O] . Bing Li, Takashi Baba, Kanako Miyabayashi, 2017

机译：Ad4结合蛋白/类系蛋白/穗类蛋白质1在肾上腺皮质Y-1细胞中调节NADPH产生的作用

Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules

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