Statistical evaluation of the in vivo micronucleus assay

Ludwig A. Hothorn; Daniel Gerhard

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Statistical evaluation of the in vivo micronucleus assay

机译：体内微核试验的统计评估

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The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed. For these statistical approaches user-friendly software is free available.

机译：体内微核分析的统计评估集中在多个对比测试中，用于比较，而阴性对照则用于计数数据，其中考虑了动物之间的变异性。对于可能的说法，该化合物在微核试验中没有遗传毒性，因此提出了安全性证明。对于这些统计方法，免费提供了用户友好的软件。

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《Archives of Toxicology》 |2009年第6期|p.625-634|共10页
作者
Ludwig A. Hothorn; Daniel Gerhard;
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1. Statistical evaluation of the in vivo micronucleus assay. [J] . Hothorn LA, Gerhard D Archives of Toxicology . 2009,第6期

机译：体内微核分析的统计评估。
2. Combined In Vivo Evaluation of Micronucleus Assay and Gene Mutation Assay Using Multi-Organs [J] . Sanada H., Ohsumi T., Yonezawa Y., Environmental and molecular mutagenesis. . 2015,第Suppla1期

机译：结合使用多器官的体内评价微核试验和基因突变试验
3. Genotoxicity evaluation of Guibi-Tang extract using an in vitro bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus test [J] . Mee-Young Lee, Chang-Seob Seo, Ji-Young Kim, BMC Complementary and Alternative Medicine . 2014,第1期

机译：Guiaibi-Tang提取物使用体外细菌反向突变测定，染色体畸变测定和体内微核试验的基因毒性评价
4. Identification of arsenic susceptibility by using the micronucleus assay and Single Nucleotide Polymorphisms (SNP) [C] . A K Bandyopadhyay, D.Chatterjee, A.K.Giri International Congress and Exhibition on Arsenic in the Environment . 2019

机译：使用微核测定和单核苷酸多态性（SNP）鉴定砷易感性（SNP）
5. The hepatocyte micronucleus assay: An in vivo genotoxicity assay in juvenile rainbow trout (Oncorhynchus mykiss) [D] . Williams, R. Chris 1992

机译：肝细胞微核试验：幼体虹鳟鱼的体内遗传毒性试验（Oncorhynchus mykiss）
6. Genotoxicity evaluation of Guibi-Tang extract using an in vitro bacterial reverse mutation assay chromosome aberration assay and in vivo micronucleus test [O] . Mee-Young Lee, Chang-Seob Seo, Ji-Young Kim, 2014

机译：使用体外细菌反向突变测定染色体畸变测定和体内微核试验评估吉比汤提取物的遗传毒性
7. In Vivo Genotoxicity Evaluation of a Stilbene Extract Prior to Its Use as a Natural Additive: A Combination of the Micronucleus Test and the Comet Assay [O] . Concepción Medrano-Padial, María Puerto, Ana Isabel Prieto, 2021

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8. Results of 4 Mutagenicity Studies (Ames Assay, in Vitro Chromosomal Aberration Study, in Vivo Rat Bone Marrow Micronucleus Test and an Unschedule DNA Synthesis Assay) as well as a 28-Day Oral Toxicity Study in Rats with 3-Sulphonylisocyanato-2-thiophene C [R] . 2009

机译：4种致突变性研究（ames试验，体外染色体畸变研究，体内大鼠骨髓微核试验和非计划DNa合成试验）的结果以及对3-磺酰异氰酸基-2-噻吩C大鼠的28天口服毒性研究

Statistical evaluation of the in vivo micronucleus assay

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