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Hydrophobic interaction of organic chemicals with microtubule assembly in vitro

机译：有机化学物质与微管组装的疏水相互作用

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A recent concept connecting the lipophilicity of organic chemicals with their genotoxicity on a chromosomal level implies that the lipophilic character of organic chemicals determines a certain background of chromosomal genotoxicity that can be addressed as “non-specific”. This is opposed to compounds with more “specific” modes of action. Such mechanisms influence the processes of karyokinesis and cytokinesis. A critical partial process for the chromosomal segregation is the dynamics of assembly and disassembly of microtubules. To broaden the present database for such interactions, chemicals were selected based on their lipophilicity (log P between −1.5 and +1.0) and on hints from the literature pointing to possibilities of interaction with the tubulin–microtubule system. Thus, acetamide, acrylamide, methylmethane sulfonate, acetonitrile, acrylonitrile and cyclohexanone were assessed as to their potencies to influence the dynamic processes of microtubule assembly and disassembly in a cell-free system in vitro. These compounds covered a range of log P between −1.5 and 1.0, complementary to compounds investigated earlier. The entire body of data supports the general concept that hydrophobic interactions are connected with non-specific processes, which contribute to a background genotoxicity on a chromosomal level. It also points to the dynamics of microtubule assembly and disassembly as a decisive partial process involved.
机译：将有机化学物质的亲脂性与其在染色体水平上的遗传毒性联系起来的最新概念表明，有机化学物质的亲脂性决定了染色体遗传毒性的某些背景，可以将其称为“非特异性”。这与具有更多“特定”作用方式的化合物相反。这样的机制影响核运动和胞质分裂的过程。染色体分离的关键部分过程是微管组装和拆卸的动力学。为了拓宽目前这种相互作用的数据库，选择化学药品是基于它们的亲脂性（log P在-1.5和+1.0之间），以及根据文献提示与微管蛋白-微管系统相互作用的可能性。因此，评估了乙酰胺，丙烯酰胺，甲基磺酸甲酯，乙腈，丙烯​​腈和环己酮的能力，以影响体外无细胞系统中微管组装和拆卸的动态过程。这些化合物的log P范围在-1.5至1.0之间，与先前研究的化合物互补。整个数据支持以下一般性概念：疏水相互作用与非特异性过程相关，这在染色体水平上促成背景遗传毒性。它还指出，微管组装和拆卸的动力学是涉及的决定性部分过程。

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