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首页> 外文期刊>Archives of Toxicology >Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats
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Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats

机译：pipe叶提取物对四氯化碳诱导的大鼠肝纤维化的保护作用

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摘要

Piper betel leaves (PBL) are used in Chinese folk medicine for the treatment of various disorders. PBL has the biological capabilities of detoxication, antioxidation, and antimutation. In this study, we evaluated the antihepatotoxic effect of PBL extract on the carbon tetrachloride (CCl4)-induced liver injury in a rat model. Fibrosis and hepatic damage, as reveled by histology and the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were induced in rats by an administration of CCl4 (8%, 1 ml/kg body weight) thrice a week for 4 weeks. PBL extract significantly inhibited the elevated AST and ALT activities caused by CCl4 intoxication. It also attenuated total glutathione S-transferase (GST) activity and GST α isoform activity, and on the other hand, enhanced superoxide dismutase (SOD) and catalase (CAT) activities. The histological examination showed the PBL extract protected liver from the damage induced by CCl4 by decreasing α-smooth muscle actin (α-sma) expression, inducing active matrix metalloproteinase-2 (MMP2) expression though Ras/Erk pathway, and inhibiting TIMP2 level that consequently attenuated the fibrosis of liver. The data of this study support a chemopreventive potential of PBL against liver fibrosis.
机译：胡椒槟榔叶（PBL）用于中草药，可治疗各种疾病。 PBL具有脱毒，抗氧化和抗突变的生物学功能。在这项研究中，我们评估了PBL提取物对四氯化碳（CCl4 ）诱导的大鼠肝损伤的抗肝毒性作用。经组织学证实，大鼠纤维化和肝损害以及通过施用CCl4 （8％，1 ml / kg体重）三次诱导大鼠的天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）活性。一周，共4周。 PBL提取物能显着抑制CCl4中毒引起的AST和ALT活性升高。它还减弱了总的谷胱甘肽S-转移酶（GST）活性和GSTα亚型活性，另一方面，增强了超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性。组织学检查显示，PBL提取物可通过降低α-平滑肌肌动蛋白（α-sma）表达，通过Ras / Erk途径诱导活性基质金属蛋白酶2（MMP2）表达来保护肝脏免受CCl4 诱导的损害。抑制TIMP2的水平，从而减弱肝脏的纤维化。这项研究的数据支持PBL对肝纤维化的化学预防潜力。

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  • 来源
    《Archives of Toxicology》 |2007年第1期|45-55|共11页
  • 作者

    Shun-Chieh Young; Chau-Jong Wang; Jing-Jing Lin; Pei-Ling Peng; Jui-Ling Hsu; Fen-Pi Chou;

  • 作者单位

    Institute of Biochemistry and Biotechnology Chung Shan Medical University No. 110 Section 2 Chien Kauo N. Road Taichung 402 Taiwan;

    Institute of Biochemistry and Biotechnology Chung Shan Medical University No. 110 Section 2 Chien Kauo N. Road Taichung 402 Taiwan;

    Institute of Biochemistry and Biotechnology Chung Shan Medical University No. 110 Section 2 Chien Kauo N. Road Taichung 402 Taiwan;

    Institute of Biochemistry and Biotechnology Chung Shan Medical University No. 110 Section 2 Chien Kauo N. Road Taichung 402 Taiwan;

    Institute of Biochemistry and Biotechnology Chung Shan Medical University No. 110 Section 2 Chien Kauo N. Road Taichung 402 Taiwan;

    Institute of Biochemistry and Biotechnology Chung Shan Medical University No. 110 Section 2 Chien Kauo N. Road Taichung 402 Taiwan;

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  • 正文语种 eng
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  • 关键词

    Piper betel leaf; Liver fibrosis; Glutathione S-transferase; α-smooth muscle actin; Matrix metalloproteinase-2;

    机译：胡椒槟榔叶;肝纤维化;谷胱甘肽S-转移酶;α-平滑肌肌动蛋白;基质金属蛋白酶-2;

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