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首页> 外文期刊>Archives of Toxicology >Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents
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Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents

机译：白蛋白中的磷酸化酪氨酸作为暴露于有机磷神经毒剂的生物标记

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摘要

The organophosphorus nerve agents sarin, soman, cyclosarin and tabun phosphylate a tyrosine residue on albumin in human blood. These adducts may offer relatively long-lived biological markers of nerve agent exposure that do not ‘age’ rapidly, and which are not degraded by therapy with oximes. Sensitive methods for the detection of these adducts have been developed using liquid chromatography-tandem mass spectrometry. Adducts of all four nerve agents were detected in the blood of exposed guinea pigs being used in studies to improve medical countermeasures. The tyrosine adducts with soman and tabun were detected in guinea pigs receiving therapy 7 days following subcutaneous administration of five times the LD50 dose of the respective nerve agent. VX also forms a tyrosine adduct in human blood in vitro but only at high concentrations.
机译：有机磷神经毒剂沙林，梭曼，环沙蛋白和塔邦磷酸化人血白蛋白上的酪氨酸残基。这些加合物可能会提供相对长期的神经毒剂暴露生物学标记，这些标记不会迅速“老化”，并且不会因肟的治疗而降解。使用液相色谱-串联质谱法已经开发出检测这些加合物的灵敏方法。在用于研究以改善医学对策的裸露豚鼠血液中检测到所有四种神经毒剂的加合物。皮下注射五倍于各自神经毒药的LD50 剂量后7天，在接受治疗的豚鼠中发现了梭曼和塔宾酪氨酸加合物。 VX在体外也可在人血中形成酪氨酸加合物，但浓度很高。

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