Trans heterodimer between two non–arthritis-associated HLA alleles can predispose to arthritis in humanized mice

Marshall Behrens; George K. Papadopoulos; Antonis Moustakas; Michele Smart; Harvinder Luthra; Chella S. David; Veena Taneja

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Trans heterodimer between two non–arthritis-associated HLA alleles can predispose to arthritis in humanized mice

机译：两个非关节炎相关的HLA等位基因之间的反式异二聚体可能使人源化小鼠易患关节炎

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Certain HLA class II alleles are associated with susceptibility to the development of arthritis. However, the development of arthritis in some persons carrying non–rheumatoid arthritis (RA)–associated alleles remains unexplained. An individual who is heterozygous for the DQA1 and DQB1 genes can express the DQ molecule in cis or trans heterodimers. In a cis heterodimer, the -chain interacts with the β-chain coded by the same chromosome, while in a trans heterodimer it interacts with the β-chain on the other chromosome. In this study, we used a humanized mouse model of arthritis in an attempt to determine whether a trans heterodimer of 2 nonassociated alleles, DQB1*0601 and DQB1*0604, can predispose to arthritis.

机译：某些HLA II类等位基因与关节炎的发展相关。但是，某些携带非类风湿关节炎（RA）相关等位基因的人的关节炎发展仍无法解释。 DQA1和DQB1基因杂合的个体可以顺式或反式异二聚体表达DQ分子。在顺式异二聚体中，-链与同一条染色体编码的β-链相互作用，而在反式异二聚体中，-链与另一条染色体上的β-链相互作用。在这项研究中，我们使用了人性化的关节炎小鼠模型来尝试确定2个非相关等位基因DQB1 * 0601和DQB1 * 0604的反式异二聚体是否易患关节炎。

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《Arthritis & Rheumatism》 |2011年第6期|1552-1561|共10页
作者
Marshall Behrens; George K. Papadopoulos; Antonis Moustakas; Michele Smart; Harvinder Luthra; Chella S. David; Veena Taneja;
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Mayo Clinic Rochester Minnesota;

Epirus Institute of Technology Arta Greece;

Technological Educational Institute of the Ionian Islands Argostoli Cephallonia Greece;

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1. Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized mice. [J] . Behrens M, Papadopoulos GK, Moustakas A, Arthritis and Rheumatism . 2011,第6期

机译：两个非关节炎相关的HLA等位基因之间的反式异二聚体可能在人源化小鼠中易患关节炎。
2. The rheumatoid arthritis-associated allele HLA-DR10 (DRB1*1001) shares part of its repertoire with HLA-DR1 (DRB1*0101) and HLA-DR4 (DRB*0401). [J] . Alvarez I, Collado J, Daura X, Arthritis and Rheumatism . 2008,第6期

机译：类风湿关节炎相关的等位基因HLA-DR10（DRB1 * 1001）与HLA-DR1（DRB1 * 0101）和HLA-DR4（DRB * 0401）共享部分库。
3. The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09 [J] . CauliA., ShawJ., GilesJ., Rheumatology . 2013,第11期

机译：与HLA-B * 27：09相比，与关节炎相关的HLA-B * 27：05等位基因为KIR3DL2形成更多的细胞表面B27二聚体和自由重链配体
4. Radiomic texture-curvature (RTC) features for precision medicine of patients with rheumatoid arthritis-associated interstitial lung disease [C] . Chinatsu Watari, Mikio Matsuhiro, Janne J. Naeppi, SPIE Medical Imaging Conference . 2018

机译：放射线纹理曲率（RTC）功能可用于类风湿关节炎相关性间质性肺病患者的精准医学
5. Ameliorating experimental autoimmune encephalomyelitis using immune modulators in humanized HLA-DR transgenic mice [D] . Somanaboeina, Animesh 2011

机译：使用免疫调节剂在人源化HLA-DR转基因小鼠中缓解实验性自身免疫性脑脊髓炎
6. Trans-heterodimer between two arthritis non-associated HLA alleles can predispose to arthritis [O] . Marshall Behrens, George K. Papadopoulos, Antonis Moustakas, -1

机译：2关节炎非相关的HLa等位基因可诱发关节炎之间的反式异二聚体
7. The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09 [O] . Cauli, Alberto, Shaw, Jacqueline, Giles, Joanna, 2017

机译：与HLA-B * 27：09相比，与关节炎相关的HLA-B * 27：05等位基因为KIR3DL2形成了更多的细胞表面B27二聚体和自由重链配体

Trans heterodimer between two non–arthritis-associated HLA alleles can predispose to arthritis in humanized mice

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