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首页> 外文期刊>Arthritis & Rheumatism >Mortality in a cohort of Danish patients with fibromyalgia: Increased frequency of suicide
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Mortality in a cohort of Danish patients with fibromyalgia: Increased frequency of suicide

机译：丹麦纤维肌痛患者队列中的死亡率：自杀频率增加

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ObjectiveA previous study demonstrated an association between self-reported widespread body pain and increased mortality. The aim of this study was to analyze whether fibromyalgia (FM) and FM-like symptoms are related to increased mortality.MethodsFrom hospital records, we identified 1,361 patients referred during the period 1984–1999 because of the suspicion of FM. The cases were reviewed by reviewers who were blinded to the outcome. The cohort was followed up for a total of 5,295 person-years at risk and was linked to the Danish Mortality Register. Using the number of years at risk and sex-, age-, and calendar-specific mortality rates from the general population, cause-specific standardized mortality ratios [SMRs] were calculated.ResultsWe observed no overall increased mortality among patients with FM. Among the 1,269 female patients, the SMRs (95% confidence intervals [95% CIs]) for an increased risk of death from suicide, liver cirrhosis/biliary tract disease, and cerebrovascular disease were 10.5 (95% CI 4.5–20.7), 6.4 (95% CI 2.3–13.9), and 3.1 (95% CI 1.1–6.8), respectively. The suicide risk was increased at the time of diagnosis and remained increased after 5 years. Patients meeting the American College of Rheumatology criteria for FM and patients with possible FM had the same cause-specific mortality pattern. No increased cause-specific mortality was observed in the 84 male patients.ConclusionThe causes of a markedly increased rate of suicide among female patients with FM are at present unknown but may be related to increased rates of lifetime depression, anxiety, and psychiatric disorders. Risk factors for suicide should be sought at the time of the diagnosis of FM and at followup. The results also suggest that risk factors for liver disease and cerebrovascular disease should be evaluated in patients with FM.
机译：目的一项先前的研究表明，自我报告的广泛身体疼痛与死亡率增加之间存在关联。这项研究的目的是分析纤维肌痛（FM）和类似FM的症状是否与死亡率增加相关。方法从医院记录中，我们确定了1984-1999年期间因怀疑FM而转诊的1,361例患者。这些病例由对结果不知情的审阅者进行了审查。对该队列进行了总共5,295人年的风险随访，并与丹麦死亡率登记册相关联。使用危险人群的年数和普通人群的性别，年龄和特定日历死亡率，计算了特定原因的标准化死亡率[SMRs]。结果我们没有观察到FM患者的总体死亡率增加。在1,269名女性患者中，因自杀，肝硬化/胆道疾病和脑血管疾病死亡风险增加的SMR（95％置信区间[95％CIs]）为10.5（95％CI 4.5–20.7），6.4 （95％CI 2.3–13.9）和3.1（95％CI 1.1–6.8）。在诊断时自杀风险增加，而在5年后仍保持增加。符合美国风湿病学会FM标准的患者和可能患有FM的患者具有相同的病因特异性死亡率模式。在84名男性患者中没有观察到因病致死的增加。结论目前尚不清楚女性FM患者自杀率显着增加的原因，但可能与终生抑郁，焦虑和精神疾病的发生率增加有关。诊断为FM时和随访时应寻找自杀的危险因素。研究结果还表明，FM患者应评估肝病和脑血管疾病的危险因素。

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  • 来源
    《Arthritis & Rheumatism》 |2010年第10期|p.3101-3108|共8页
  • 作者

    Lene Dreyer; Sally Kendall; Bente Danneskiold-Samsøe; Else Marie Bartels; Henning Bliddal;

  • 作者单位

    Copenhagen University, Copenhagen University Hospital, and Rigshospitalet, Copenhagen, and Frederiksberg Hospital, Frederiksberg, Denmark;

    Frederiksberg Hospital, Frederiksberg, Denmark;

    Copenhagen University, Copenhagen, Frederiksberg Hospital, Frederiksberg, and Aalborg University, Aalborg, Denmark;

    Frederiksberg Hospital, Frederiksberg, Denmark;

    Copenhagen University, Copenhagen, Frederiksberg Hospital, Frederiksberg, and Aalborg University, Aalborg, Denmark;

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