Automated Optimal Design of Mechanical Conformational Switches

Saitou K; Jakiela M

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Automated Optimal Design of Mechanical Conformational Switches

机译：机械构象开关的自动优化设计

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摘要

Bacteriophage viruses spontaneously self-assemble in the presence of their component parts (certain protein molecules). It is believed that conformational switches, interacting chemical bonding sites that allow tentative incorrect bonds, facilitate this randomized assembly process. A one-dimensional conformational switch is proposed and used to study the randomized assembly of mechanical parts. A genetic algorithm is used to search the space of parameterized switch designs to maximize the rate of a desired assembly.

机译：噬菌体病毒在其组成部分（某些蛋白质分子）存在的情况下自发自组装。据信构象开关与相互作用的化学键合位点相互作用，允许暂时的错误键合，促进了这种随机组装过程。提出了一种一维构象开关，并用于研究机械零件的随机组装。遗传算法用于搜索参数化开关设计的空间，以最大程度地提高所需装配的速率。

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来源
《Artificial Life》 |1995年第2期|129-156|共28页
作者
Saitou K; Jakiela M;
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作者单位

Computer-Aided Design Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 3-46la, Cambridge, MA 02139 USA. kazu@mit.edu;

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原文格式 PDF
正文语种 eng
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关键词
genetic optimization; ntttmechanical conformational switches; ntttrandomized assembly;

机译：基因优化;nttt机械构象开关;nnttrandomized大会;

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8. AN IMPROVED METHOD FOR OPTIMUM DESIGN OF MECHANICALLY AND THERMALLY LOADED STRUCTURES [R] . Howard M. Adelman, Joanne L. Walsh, R. Narayanaswami 1975

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Automated Optimal Design of Mechanical Conformational Switches

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