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首页> 外文期刊>Artificial Organs >Improvement of Intradialytic Hypotension in Diabetic Hemodialysis Patients Using Vitamin E-Bonded Polysulfone Membrane Dialyzers
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Improvement of Intradialytic Hypotension in Diabetic Hemodialysis Patients Using Vitamin E-Bonded Polysulfone Membrane Dialyzers

机译：维生素E结合的聚砜膜透析仪改善糖尿病血液透析患者的透析内低血压

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Currently, there are no detailed reports on the effects of vitamin E-bonded polysulfone (PS) membrane dialyzers on intradialytic hypotension (IDH) in diabetic hemodialysis (HD) patients. This study was designed to evaluate changes in intradialytic systolic blood pressure (SBP) using “VPS-HA” vitamin E-bonded super high-flux PS membrane dialyzers. The subjects were 62 diabetic HD patients whose intradialytic SBP fell by more than 20%. Group A comprised patients who required vasopressors to be able to continue treatment or who had to discontinue therapy due to their lowest intradialytic SBP being observed at 210?min (28 patients). Group B comprised patients who showed no symptoms and required no vasopressors but showed a gradual reduction in blood pressure, with the lowest intradialytic SBP seen at the end of dialysis (34 patients). The primary outcome was defined as the lowest intradialytic SBP after 3 months using VPS-HA. Secondary outcomes included changes in the following: lowest intradialytic diastolic blood pressure, pulse pressure, pulse rate, plasma nitric oxide and peroxynitrite, serum albumin, and hemoglobin A1c. Group A's lowest intradialytic SBP had significantly improved at 3 months (128.0?±? 25.1?mm?Hg vs. 117.1?±?29.2?mm?Hg; P?=?0.017). Group B's lowest intradialytic SBP had significantly improved at 1 month (134.4?±?13.2?mm?Hg vs. 121.5?±?25.8?mm?Hg; P?=? 0.047) and 3 months (139.1?±?20.9?mm?Hg vs. 121.5?±? 25.8?mm?Hg; P?=?0.011). We conclude that VPS-HA may improve IDH in diabetic HD patients.
机译：目前，尚无关于维生素E键聚砜（PS）膜透析器对糖尿病血液透析（HD）患者透析内低血压（IDH）的影响的详细报道。本研究旨在评估使用“ VPS-HA”维生素E键合的超高通量PS膜透析器的透析内收缩压（SBP）的变化。受试者为62名糖尿病HD患者，其透析内SBP下降了20％以上。 A组包括需要血管加压药才能继续治疗或由于在210？min观察到最低的透析内SBP而不得不中止治疗的患者（28例）。 B组包括无症状，不需要升压药但血压逐渐降低的患者，透析结束时透析内SBP最低（34例）。主要结果定义为使用VPS-HA透析3个月后最低的SBP。次要结果包括以下变化：最低的透析内舒张压，脉压，脉搏率，血浆一氧化氮和过氧亚硝酸盐，血清白蛋白和血红蛋白A1c。 A组最低的透析内SBP在3个月时有明显改善（128.0±±25.1mmmmHg，而117.1±±29.2mmmmHg； P <= 0.017）。 B组最低的透析内收缩压在1个月（134.4±±13.2mmmmHg与121.5±±25.8mmmmHg;P≥0.047）和3个月（139.1±±20.9mm）显着改善。 Hg vs.121.5mm±Hg 25.8mmmmHg； P1 ＝ 0.011。我们得出结论，VPS-HA可以改善糖尿病HD患者的IDH。

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