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首页> 外文期刊>Artificial Organs >Rescue Extracorporeal Life Support for Acute Verapamil and Propranolol Toxicity in a Neonate
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Rescue Extracorporeal Life Support for Acute Verapamil and Propranolol Toxicity in a Neonate

机译：抢救新生儿维拉帕米和普萘洛尔毒性的体外生命支持。

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摘要

Extracorporeal life support (ECLS) to manage acute antiarrhythmic drugs toxicity in neonates has never been reported. Here presented is a case of venoarterial extracorporeal membrane oxygenation support in a newborn with refractory low cardiac output as a result of acute Ca-channel and β-receptor antagonist toxicity for treatment of paroxysmal supraventricular tachycardia (SVT). Shortly after onset of ECLS, the baby recovered sinus rhythm and subsequent bouts of SVT were controlled by amiodarone infusion and repeated DC shocks. Weaning was possible on the 5th day after implant, once recovery of the left ventricular function and optimization of the antiarrhythmic medication were achieved. In neonates with severe but potentially reversible cardiac dysfunction caused by drug toxicity, ECLS can maintain cardiac output and vital organ perfusion while allowing time for drug redistribution, metabolism, and clearance.
机译：从未报道过用于管理新生儿急性抗心律不齐药物毒性的体外生命支持（ECLS）。本文介绍了由于急性Ca通道和β受体拮抗剂毒性治疗阵发性室上性心动过速（SVT）而导致难治性低心输出量的新生儿静脉动脉体外膜氧合作用的案例。 ECLS发作后不久，婴儿已恢复窦性心律，随后通过胺碘酮输注和反复的DC电击控制了SVT发作。植入后第5天即可断奶，一旦左心功能恢复并优化抗心律失常药物即可。在因药物毒性而导致严重但潜在可逆的心脏功能障碍的新生儿中，ECLS可以维持心输出量和重要器官灌注，同时留出时间进行药物的重新分配，代谢和清除。

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