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Computer-Assisted Numerical Analysis for Oxygen and Carbon Dioxide Mass Transfer in Blood Oxygenators

机译：血氧仪中氧气和二氧化碳传质的计算机辅助数值分析

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摘要

A two-dimensional numeric simulator is developed to predict the nonlinear, convective-reactive, oxygen mass exchange in a cross-flow hollow fiber blood oxygenator. The numeric simulator also calculates the carbon dioxide mass exchange, as hemoglobin affinity to oxygen is affected by the local pH value, which depends mostly on the local carbon dioxide content in blood. Blood pH calculation inside the oxygenator is made by the simultaneous solution of an equation that takes into account the blood buffering capacity and the classical Henderson–Hasselbach equation. The modeling of the mass transfer conductance in the blood comprises a global factor, which is a function of the Reynolds number, and a local factor, which takes into account the amount of oxygen reacted to hemoglobin. The simulator is calibrated against experimental data for an in-line fiber bundle. The results are: (i) the calibration process allows the precise determination of the mass transfer conductance for both oxygen and carbon dioxide; (ii) very alkaline pH values occur in the blood path at the gas inlet side of the fiber bundle; (iii) the parametric analysis of the effect of the blood base excess (BE) shows that is similar in the case of blood metabolic alkalosis, metabolic acidosis, or normal BE, for a similar blood inlet , although the condition of metabolic alkalosis is the worst case, as the pH in the vicinity of the gas inlet is the most alkaline; (iv) the parametric analysis of the effect of the gas flow to blood flow ratio (QG/QB) shows that variation with the gas flow is almost linear up to QG/QB = 2.0. is not affected by the gas flow as it was observed that by increasing the gas flow up to eight times, the grows only 1%. The mass exchange of carbon dioxide uses the full length of the hollow-fiber only if QG/QB > 2.0, as it was observed that only in this condition does the local variation of pH and blood comprise the whole fiber bundle.
机译：开发了一种二维数值模拟器，以预测错流中空纤维血液充氧器中的非线性，对流反应性氧气质量交换。数值模拟器还计算二氧化碳的质量交换，因为血红蛋白对氧气的亲和力受局部pH值的影响，该pH值主要取决于血液中局部的二氧化碳含量。充氧器内部的血液pH值计算是通过同时考虑血液缓冲能力和经典的Henderson-Hasselbach方程的方程式进行的。血液中传质电导的模型包括一个全局因子和一个局部因子，该全局因子是雷诺数的函数，局部因子考虑了与血红蛋白反应的氧气量。针对在线光纤束的实验数据对模拟器进行了校准。结果是：（i）校准过程可以精确确定氧气和二氧化碳的传质电导率； （ii）在纤维束的气体入口侧的血液路径中出现非常碱性的pH值； （iii）对血碱过多（BE）影响的参数分析表明，对于血液入口类似的血液，血液代谢性碱中毒，代谢性酸中毒或正常BE的情况相似，尽管代谢性碱中毒的情况是最坏的情况是，进气口附近的pH值最碱性； （iv）对气体流量与血液流量之比（Q G / Q B ）影响的参数分析表明，直到Q G / Q B = 2.0。不受气流影响，因为观察到通过将气流增加到八倍，增长率仅增加了1％。二氧化碳的质量交换仅在Q G / Q B

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