• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Artificial Organs >Teicoplanin Pharmacokinetics During Albumin Dialysis
【24h】

Teicoplanin Pharmacokinetics During Albumin Dialysis

机译：白蛋白透析期间替考拉宁的药代动力学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Teicoplanin (TP) pharmacokinetics was assessed in a critically ill patient during albumin dialysis (AD), which was performed with the molecular adsorbent recirculating system. After a 1200-mg loading dose (24?mg/kg), doses of 1200 and 1000?mg (20?mg/kg) on day 2 and 3, respectively, were administered during two cycles of AD. The mean TP peak and trough concentrations amounted to 99.3 and 21.4?μg/mL, respectively, during AD. A mean half-life of 5.5?h, an apparent volume of distribution of 0.302?L/kg, and a mean total TP clearance of 39?mL/h/kg were calculated. Ninety minutes after the start of AD, the extracorporeal clearance was 3560?mL/h. Within 8?h of AD therapy, the serum concentrations decreased by about 75%. Despite a considerable elimination of TP by AD, therapeutic serum levels could be maintained during the entire treatment by administration of high doses and close monitoring of TP serum concentrations.
机译：在白蛋白透析（AD）期间，对重症患者的Teicoplanin（TP）药代动力学进行了评估，这是通过分子吸附剂再循环系统进行的。 1200 mg负荷剂量（24？mg / kg）后，在两个AD周期中分别在第2天和第3天给予1200和1000？mg（20？mg / kg）剂量。在AD期间，平均TP峰和谷浓度分别为99.3和21.4μg/ mL。计算的平均半衰期为5.5？h，表观分布体积为0.302？L / kg，平均总TP清除率为39？mL / h / kg。 AD开始后90分钟，体外清除率为3560？mL / h。在AD治疗的8小时内，血清浓度降低了约75％。尽管AD显着消除了TP，但在整个治疗过程中，可通过给予高剂量并密切监测TP血清浓度来维持治疗性血清水平。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号