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首页> 外文期刊>Asian Journal of Andrology >Seminal plasma anti-Muellerian hormone level correlates with semen parameters but does not predict success of testicular sperm extraction (TESE)
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Seminal plasma anti-Muellerian hormone level correlates with semen parameters but does not predict success of testicular sperm extraction (TESE)

机译：精浆中的抗穆勒（Muellerian）激素水平与精液参数相关，但不能预测睾丸精子提取（TESE）成功

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Aim: To assess seminal plasma anti-Muellerian hormone (AMH) leval relationships in fertile and infertile males. Methods: Eighty-four male cases were studied and divided into four groups: fertile normozoospermia (n = 16), oligoastheno-teratozoospermia (n = 15), obstructive azoospermia (OA) (n = 13) and non-obstructive azoospermia (NOA) (n = 40). Conventional semen analysis was done for all cases. Testicular biopsy was done with histopathology and fresh tissue examination for testicular sperm extraction (TESE) in NOA cases. NOA group was subdivided according to TESE results into unsuccessful TESE (n = 19) and successful TESE (n = 21). Seminal plasma AMH was estimated by enzyme linked immunosorbent assay (ELISA) and serum follicular stimulating hormone (FSH) was estimated in NOA cases only by radioimmunoassay (RIA). Results: Mean seminal AMH was significantly higher in fertile group than in oligoasthenoteratozoospermia with significance (41.5 ± 10.9 pmol/L vs. 30.5 ± 10.3 pmol/L, P < 0.05). Seminal AMH was not detected in any OA patients. Seminal AMH was correlated positively with testicular volume (r = 0.329, P = 0.005), sperm count (r = 0.483, P = 0.007), sperm motility percent (r = 0.419, P = 0.021) and negatively with sperm abnormal forms percent (r = -0.413, p = 0.023). Nonsignificant correlation was evident with age (r = -0.155, P = 0.414) and plasma FSH ( r = -0.014, P = 0.943). In NOA cases, seminal AMH was detectable in 23/40 cases, 14 of them were successful TESE (57.5%) and was undetectable in 17/40 cases, 10 of them were unsuccessful TESE (58.2%). Conclusion: Seminal plasma AMH is an absolute testicular marker being absent in all OA cases. However, seminal AMH has a poor predictability for successful testicular sperm retrieval in NOA cases.
机译：目的：评估可育和不育男性的精浆血浆抗穆勒氏激素（AMH）水平关系。方法：对84例男性病例进行研究，将其分为四组：可育的正常精子症（n = 16），少精子症-畸胎性精子症（n = 15），梗阻性无精子症（OA）（n = 13）和非阻塞性无精子症（NOA）。 （n = 40）。所有病例均进行常规精液分析。在NOA病例中，通过组织病理学和新鲜组织检查进行睾丸活检，以进行睾丸精子提取（TESE）。根据TESE结果将NOA组细分为不成功的TESE（n = 19）和成功的TESE（n = 21）。仅通过放射免疫法（RIA）通过酶联免疫吸附测定（ELISA）评估精浆血浆AMH，而在NOA病例中评估血清卵泡刺激素（FSH）。结果：受精组的平均精液AMH显着高于少脂非小动物精子症（41.5±10.9 pmol / L vs. 30.5±10.3 pmol / L，P <0.05）。在任何OA患者中均未检测到精液AMH。精液AMH与睾丸体积（r = 0.329，P = 0.005），精子计数（r = 0.483，P = 0.007），精子活力百分比（r = 0.419，P = 0.021）正相关，与精子异常形式百分比（r = 0.419，P = 0.021）正相关。 r = -0.413，p = 0.023）。与年龄（r = -0.155，P = 0.414）和血浆FSH（r = -0.014，P = 0.943）的关系不明显。在NOA病例中，精液AMH在23/40例中可检测到，其中14例成功通过TESE（57.5％），在17/40例中未检测到，其中10例未通过TESE（58.2％）。结论：精浆AMH是所有OA患者均不存在的绝对睾丸标志物。然而，在NOA病例中，精液AMH对于睾丸精子成功取回的可预测性较差。

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