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首页> 外文期刊>Asian Journal of Andrology >Novel flutamide regulated genes in the rat ventral prostate: differential modulation of their expression by castration and flutamide treatments
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Novel flutamide regulated genes in the rat ventral prostate: differential modulation of their expression by castration and flutamide treatments

机译：大鼠腹侧前列腺中新的氟他胺调节基因：去势和氟他胺治疗对其表达的差异调节

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Aim: To identify flutamide regulated genes in the rat ventral prostate. Methods: Total RNA from ventral prostates of control and flutamide treated rats were isolated. Differentially expressed transcripts were identified using differential display reverse transcriptase polymerase chain reaction. The effect of castration on the expression of flutamide-regulated transcripts was studied. Results: We have identified β2-microglobulin, cytoplasmic FMR1 interacting protein 2 and pumilio 1 as flutamide induced and spermine binding protein and ribophorin II as flutamide repressed targets in the rat ventral prostate. Although flutamide treatment caused an induction of pumilio 1 mRNA, castration had no effect. Conclusion: Castration and flutamide treatments exert differential effects on gene expression. Flutamide might also have direct AR independent effects, which might have implications in the emergence of androgen independent prostate cancer and the failure of flutamide therapy.
机译：目的：鉴定大鼠腹侧前列腺中氟他胺调节的基因。方法：从对照组和氟他胺治疗的大鼠的腹侧前列腺中提取总RNA。使用差异显示逆转录酶聚合酶链反应鉴定差异表达的转录物。研究了去势对氟他胺调节的转录物表达的影响。结果：我们已经确定β2-微球蛋白，胞质FMR1相互作用蛋白2和pumilio 1是氟他胺诱导的，精胺结合蛋白和核糖蛋白II是氟他胺抑制的大鼠腹侧前列腺的靶标。尽管氟他胺治疗引起了pumilio 1 mRNA的诱导，但去势没有作用。结论：去势和氟他胺治疗对基因表达有不同的作用。氟他胺可能还具有直接的AR独立作用，这可能与雄激素非依赖性前列腺癌的出现和氟他胺治疗的失败有关。

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