...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Asian Journal of Andrology >Apoptotic Sertoli cell death in hypogonadic (hgn/hgn) rat testes during early postnatal development
【24h】

Apoptotic Sertoli cell death in hypogonadic (hgn/hgn) rat testes during early postnatal development

机译：性腺功能减退（hgn / hgn）大鼠睾丸在出生后早期发育过程中凋亡的支持细胞死亡

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim: To determine the involvement of apoptotic cell death in postnatal pathogenesis in mutant strain of hypogonadic (hgn/hgn) rats testes. We evaluated the numbers and types of cells undergoing apoptotic cell death. Methods: Tissue sections were stained by the TUNEL method for in situ detection of apoptotic cells, with specific antibodies used as markers of testicular somatic and germ cells. Results: We found that apoptosis in the hgn/hgn testes during the early postnatal period occurred primarily in Sertoli cells, which should actively proliferate during this stage of differentiation. These findings strongly suggest that the normal allele of hgn is involved in the direct or indirect control of differentiation and proliferation of Sertoli cells. Conclusion: To our knowledge, this is the first report demonstrating early postnatal apoptosis of Sertoli cells, suggesting that the hgn/hgn rat is a unique model for the study of Sertoli cell deficiency.
机译：目的：确定性腺功能低下（hgn / hgn）大鼠睾丸突变株中凋亡细胞死亡与出生后发病机制的关系。我们评估了凋亡细胞死亡的细胞数量和类型。方法：采用TUNEL法对组织切片进行染色，原位检测凋亡细胞，并用特异性抗体作为睾丸体细胞和生殖细胞的标志物。结果：我们发现出生后早期的hgn / hgn睾丸中的凋亡主要发生在Sertoli细胞中，在分化的这一阶段应活跃地增殖。这些发现强烈表明，hgn的正常等位基因直接或间接控制了支持细胞的分化和增殖。结论：据我们所知，这是第一个证明支持细胞早期凋亡的报道，这表明hgn / hgn大鼠是研究支持细胞缺乏的独特模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号