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首页> 外文期刊>Asian Journal of Andrology >Androgenic effect of Mondia whitei roots in male rats
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Androgenic effect of Mondia whitei roots in male rats

机译：Mondia whitei根对雄性大鼠的雄激素作用。

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Aim: To determine the effect of the aqueous extract of Mondia whitei (Periplocaceae) roots on testosterone production and fertility of male rats. Methods: Adult male Wistar rats were used. In the acute study, 20 rats were randomly divided into 5 groups of 4 animals each. Four treated groups were administered orally a single dose of Mondia whitei (400 mg/kg) and the controls received a similar amount of distilled water. One group of animals were sacrificed by cervical dislocation 1, 2, 4 and 6 h after treatment, respectively. The controls were sacrificed at 6 h. Testicular testosterone was determined by radioimmunoassay. In the chronic study, 28 rats were divided at random into 4 groups of 7 animals each: Groups 1, 2 and 3 were given orally the plant extract (400 mg-kg~(-1) ·May~(-1)) for 2, 4 and 8 days, respectively. The animals of Groups 1 and 2 were sacrificed 24 hours after the last dosing. The controls (Group 4) received the same amount of distilled water for 8 days. The fertility was assessed only in Groups 3 and 4 and after that, the animals were sacrificed and the epididymal sperm density, the serum testosterone and the testicular testosterone and 17β-estradiol were assayed. The serum, testicular and epidydimal protein contents were also determined. Results: In the acute treatment groups, the serum and testicular concentrations of testosterone remained unchanged at all the time points. Chronic treatment for 8 days induced a significant increase in the testicular weight, the serum and testicular testosterone, the testicular protein content and the sperm density (P< 0.05-0.01), but did not affect the accessory gland weights, the serum protein contents, the testicular concentration of 17β-estradiol and the fertility compared to the controls. Conclusion: Mondia whitei root extract possesses an androgenic property.
机译：目的：确定蒙地亚（Perdialocaceae）根水提物对雄性大鼠睾丸激素产生和生育能力的影响。方法：使用成年雄性Wistar大鼠。在急性研究中，将20只大鼠随机分为5组，每组4只。四个治疗组口服单剂量的Mondia whitei（400 mg / kg），对照组接受相似量的蒸馏水。分别在治疗后1、2、4和6小时通过颈脱位法处死一组动物。在6小时处死对照。通过放射免疫测定法测定睾丸睾丸激素。在慢性研究中，将28只大鼠随机分为4组，每组7只动物：第1、2和3组口服给予植物提取物（400 mg-kg〜（-1）·May〜（-1））用于治疗。第2、4和8天。在最后一次给药后24小时处死第1组和第2组的动物。对照组（第4组）接受相同量的蒸馏水，持续8天。仅在第3和第4组中评估生育力，然后处死动物，并测定附睾的精子密度，血清睾丸激素和睾丸睾丸激素以及17β-雌二醇。还测定了血清，睾丸和附睾蛋白质含量。结果：在急性治疗组中，睾丸激素的血清和睾丸浓度在所有时间点均保持不变。慢性治疗8天后，睾丸重量，血清和睾丸睾丸激素，睾丸蛋白质含量和精子密度显着增加（P <0.05-0.01），但不影响副腺体重量，血清蛋白质含量，与对照组相比，睾丸中17β-雌二醇的浓度和生育能力。结论：蒙地亚白根提取物具有雄激素特性。

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