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Approaches to post-testicular contraception

机译:睾丸后避孕的方法

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The induction of infertility in makes of several species through epididyma interference is more difficult to achieve by reduction of the amounts of epididymal secretions (eg α-gucosidase, L-carnitine) or immunological interference with escorted proteins (eg D/E, P34H, P26h) than by direct actions of drugs on sperm function (eg inhibition of glyceraldehyde 3-phosphate dehydrogenate by chloro-compounds). The attar approach holds promise for mankind as human sperm are susceptible to glycoytic inhibition. Future contraceptive developments may arise from production of targeted inhibitors, research on the displacement of sperm proteins in the epididynmis and interference with sperm plasma membrane ion channels.
机译:通过减少附睾分泌物(例如α-古柯糖苷酶,L-肉碱)或对伴随蛋白的免疫干扰(例如D / E,P34H,P26h),通过附睾干扰在几种物种的不育中诱导不易诱导),而不是通过药物对精子功能的直接作用(例如,氯化合物抑制3-磷酸甘油醛脱氢)。 Attar方法为人类带来了希望,因为人类的精子容易受到糖基化抑制。避孕药的未来发展可能来自于靶向抑制剂的生产,对附睾中精子蛋白置换的研究以及对精子质膜离子通道的干扰。

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