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首页> 外文期刊>Astrobiology >Effects of Simulated Space Radiation on Immunoassay Components for Life-Detection Experiments in Planetary Exploration Missions
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Effects of Simulated Space Radiation on Immunoassay Components for Life-Detection Experiments in Planetary Exploration Missions

机译：模拟空间辐射对行星探测任务生命检测实验中免疫测定成分的影响

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摘要

The Life Marker Chip (LMC) instrument is part of the proposed payload on the ESA ExoMars rover that is scheduled for launch in 2018. The LMC will use antibody-based assays to detect molecular signatures of life in samples obtained from the shallow subsurface of Mars. For the LMC antibodies, the ability to resist inactivation due to space particle radiation (both in transit and on the surface of Mars) will therefore be a prerequisite. The proton and neutron components of the mission radiation environment are those that are expected to have the dominant effect on the operation of the LMC. Modeling of the radiation environment for a mission to Mars led to the calculation of nominal mission fluences for proton and neutron radiation. Various combinations and multiples of these values were used to demonstrate the effects of radiation on antibody activity, primarily at the radiation levels envisaged for the ExoMars mission as well as at much higher levels. Five antibodies were freeze-dried in a variety of protective molecular matrices and were exposed to various radiation conditions generated at a cyclotron facility. After exposure, the antibodies' ability to bind to their respective antigens was assessed and found to be unaffected by ExoMars mission level radiation doses. These experiments indicated that the expected radiation environment of a Mars mission does not pose a significant risk to antibodies packaged in the form anticipated for the LMC instrument.
机译：生命标记芯片（LMC）仪器是ESA ExoMars火星探测器拟议有效载荷的一部分，该探测器计划于2018年发射。LMC将使用基于抗体的测定法来检测从火星浅表层获得的样品中生命的分子特征。 。因此，对于LMC抗体，必须具有抵抗由于空间粒子辐射（在运输过程中和在火星表面上）引起的失活的能力。任务辐射环境中的质子和中子成分是那些预计将对LMC的运行产生主要影响的成分。对火星飞行任务的辐射环境进行建模，可以计算出质子和中子辐射的名义飞行任务注量。这些值的各种组合和倍数用于证明辐射对抗体活性的影响，主要是在ExoMars任务设想的辐射水平以及更高水平下。将五种抗体在各种保护性分子基质中冷冻干燥，并暴露于回旋加速器设施产生的各种辐射条件下。暴露后，评估抗体结合其各自抗原的能力，发现不受ExoMars任务级辐射剂量的影响。这些实验表明，火星任务的预期辐射环境不会对以LMC仪器预期形式包装的抗体构成重大风险。

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  • 来源
    《Astrobiology》 |2012年第8期|718-729|共12页
  • 作者

    Mariliza Derveni; Alex Hands; Marjorie Allen; Mark R. Sims; David C. Cullen;

  • 作者单位

    Cranfield Health, Cranfield University, Cranfield, Bedfordshire, United Kingdom,Cranfield Health Vincent Building Cranfield University Cranfield-Bedford MK43 OAL UK;

    QinetiQ, Aerospace Division, Farnborough, Hampshire, United Kingdom;

    Cranfield Health, Cranfield University, Cranfield, Bedfordshire, United Kingdom;

    Space Research Centre, Department of Physics and Astronomy, University of Leicester, Leicester, United Kingdom;

    Cranfield Health, Cranfield University, Cranfield, Bedfordshire, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    life-detection instruments; planetary habitability and bio-signatures; radiation; mars; life in extreme environments;

    机译：生命探测仪器;行星的可居住性和生物特征;辐射;火星;极端环境中的生活;

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