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首页> 外文期刊>Astrobiology >Adsorption of Amino Acids (Ala, Cys, His, Met) on Zeolites: Fourier Transform Infrared and Raman Spectroscopy Investigations
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Adsorption of Amino Acids (Ala, Cys, His, Met) on Zeolites: Fourier Transform Infrared and Raman Spectroscopy Investigations

机译：沸石上氨基酸（Ala，Cys，His，Met）的吸附：傅立叶变换红外和拉曼光谱研究

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摘要

Minerals adsorb more amino acids with charged R-groups than amino acids with uncharged R-groups. Thus, the peptides that form from the condensation of amino acids on the surface of minerals should be composed of amino acid residues that are more charged than uncharged. However, most of the amino acids (74%) in today's proteins have an uncharged R-group. One mechanism with which to solve this paradox is the use of organo-philic minerals such as zeolites. Over the range of pH (pH 2.66-4.50) used in these experiments, the R-group of histidine (His) is positively charged and neutral for alanine (Ala), cysteine (Cys), and methionine (Met). In acidic hydrothermal environments, the pH could be even lower than those used in this study. For the pH range studied, the zeolites were negatively charged, and the overall charge of all amino acids was positive. The conditions used here approximate those of prebiotic Earth. The most important finding of this work is that the relative concentrations of each amino acid (X = His, Met, Cys) to alanine (X/Ala) are close to 1.00. This is an important result with regard to prebiotic chemistry because it could be a solution for the paradox stated above. Pore size did not affect the adsorption of Cys and Met on zeolites, and the Si/Al ratio did not affect the adsorption of Cys, His, and Met. ZSM-5 could be used for the purification of Cys from other amino acids (Student-Newman-Keuls test, p<0.05), and mordenite could be used for separation of amino acids from each other (Student-Newman-Keuls test, p<0.05). As shown by Fourier transform infrared (FT-IR) spectra, Ala interacts with zeolites through the NH^ group, and methionine-zeolite interactions involve the COO, NHj1", and CH3 groups. FT-IR spectra show that the interaction between the zeolites and His is weak. Cys showed higher adsorption on all zeolites; however, the hydrophobic Van der Waals interaction between zeolites and Cys is too weak to produce any structural changes in the Cys groups (amine, carboxylic, sulfhydryl, etc.); thus, the FT-IR and Raman spectra are the same as those of solid Cys.
机译：矿物质比带不带电荷的R-基团的氨基酸吸收更多的氨基酸。因此，由矿物质表面氨基酸缩合形成的肽应由带电荷比不带电荷的氨基酸残基组成。但是，当今蛋白质中的大多数氨基酸（74％）具有不带电荷的R-基团。解决这一矛盾的一种机制是使用亲有机矿物，例如沸石。在这些实验中使用的pH值范围（pH 2.66-4.50）中，组氨酸（His）的R-基带正电荷，对丙氨酸（Ala），半胱氨酸（Cys）和蛋氨酸（Met）呈中性。在酸性热液环境中，pH可能甚至低于本研究中使用的pH。在研究的pH范围内，沸石带负电，所有氨基酸的总电荷为正。这里使用的条件近似于益生元地球的条件。这项工作最重要的发现是每种氨基酸（X = His，Met，Cys）与丙氨酸（X / Ala）的相对浓度接近1.00。对于益生元化学而言，这是重要的结果，因为它可能是上述矛盾的解决方案。孔径不影响Cys和Met在沸石上的吸附，并且Si / Al比不影响Cys，His和Met的吸附。 ZSM-5可用于从其他氨基酸中纯化半胱氨酸（Student-Newman-Keuls试验，p <0.05），丝光沸石可用于彼此分离氨基酸（Student-Newman-Keuls试验，p <0.05）。如傅立叶变换红外光谱（FT-IR）所示，Ala通过NH ^基团与沸石相互作用，而蛋氨酸-沸石相互作用涉及COO，NHj1“和CH3基团。FT-IR光谱表明沸石之间的相互作用Cys对所有沸石均具有较高的吸附性；但是，沸石与Cys之间的疏水范德华相互作用太弱，无法在Cys基团（胺，羧基，巯基等）上产生任何结构变化；因此， FT-IR和拉曼光谱与固态Cys相同。

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  • 来源
    《Astrobiology》 |2011年第5期|p.409-418|共10页
  • 作者

    Cristine E.A. Carneiro; Henrique de Santana; Clara Casado; Joaquin Coronas; Dimas A. M. Zaia;

  • 作者单位

    Departamento de Quimica-CCE, Universidade Estadual de Londrina, Londrina-PR, Brazil;

    Departamento de Quimica-CCE, Universidade Estadual de Londrina, Londrina-PR, Brazil;

    Chemical and Environmental Engineering Department and Nanoscience Institute of Aragon, Universidad de Zaragoza, Zaragoza, Spain;

    Chemical and Environmental Engineering Department and Nanoscience Institute of Aragon, Universidad de Zaragoza, Zaragoza, Spain;

    Departamento de Quimica-CCE, Universidade Estadual de Londrina, Londrina-PR, Brazil;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    zeolites-amino acids-adsorption-side chains-prebiotic chemistry;

    机译：沸石-氨基酸-吸附侧链-益生元化学;

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