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首页> 外文期刊>Acta astronautica >Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading
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Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading

机译：成熟的成骨细胞中胰岛素样生长因子-1受体是重载诱导骨膜形成骨所必需的

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摘要

Skeletal loading and unloading has a pronounced impact on bone remodeling, a process also regulated by insulin-like growth factor-1 (IGF-1) signaling. Skeletal unloading leads to resistance to the anabolic effect of IGF-1, while reloading after unloading restores responsiveness to IGF-1. However, a direct study of the importance of IGF-1 signaling in the skeletal response to mechanical loading remains to be tested. In this study, we assessed the skeletal response of osteoblast-specific Igf-l receptor deficient (Igf-1r~(-/-)) mice to unloading and reloading. The mice were hindlimb unloaded for 14 days and then reloaded for 16 days. Igf-1r~(-/-) mice displayed smaller cortical bone and diminished periosteal and endosteal bone formation at baseline. Periosteal and endosteal bone formation decreased with unloading in Igf-1r~(+/+) mice. However, the recovery of periosteal bone formation with reloading was completely inhibited in Igf-1r~(-/-) mice, although reloading-induced endosteal bone formation was not hampered. These changes in bone formation resulted in the abolishment of the expected increase in total cross-sectional area with reloading in Igf-1r~(-/-) mice compared to the control mice. These results suggest that the Igf-1r in mature osteoblasts has a critical role in periosteal bone formation in the skeletal response to mechanical loading.
机译：骨骼的装卸对骨骼重塑有明显影响，骨骼重塑也受胰岛素样生长因子-1（IGF-1）信号传导的调节。骨骼的卸载导致对IGF-1合成代谢作用的抵抗，而卸载后的重新加载可恢复对IGF-1的响应。但是，直接研究IGF-1信号在骨骼对机械负荷反应中的重要性的直接研究仍有待测试。在这项研究中，我们评估了成骨细胞特异性Igf-1受体缺陷（Igf-1r〜（-/-））小鼠对骨骼卸载和重新加载的骨骼反应。将小鼠后肢卸载14天，然后再加载16天。 Igf-1r〜（-/-）小鼠在基线时显示出较小的皮质骨，并减少了骨膜和骨内膜骨的形成。随着Igf-1r〜（+ / +）小鼠的卸荷，骨膜和骨内膜骨形成减少。然而，尽管重载诱导的骨内膜骨形成没有受到阻碍，但在Igf-1r〜（-/-）小鼠中，重载骨膜后骨形成的恢复被完全抑制。与对照小鼠相比，Igf-1r〜（-/-）小鼠中的骨重装导致这些总横截面面积的预期增加，而不再增加Igf-1r〜（-/-）小鼠。这些结果表明，成熟成骨细胞中的Igf-1r在骨膜对机械负荷的骨骼反应中起着至关重要的作用。

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  • 来源
    《Acta astronautica》 |2013年第1期|73-78|共6页
  • 作者

    Takuo Kubota; Hashem Z. Elalieh; Neema Saless; Chak Fong; Yongmei Wang; Muriel Babey; Zhiqiang Cheng; Daniel D. Bikle;

  • 作者单位

    Department of Medicine, University of California San Francisco and Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement St, 111N, San Francisco, CA 94121, USA,First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka, Japan,Department of Pediatrics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan;

    Department of Medicine, University of California San Francisco and Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement St, 111N, San Francisco, CA 94121, USA;

    Department of Medicine, University of California San Francisco and Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement St, 111N, San Francisco, CA 94121, USA;

    Department of Medicine, University of California San Francisco and Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement St, 111N, San Francisco, CA 94121, USA;

    Department of Medicine, University of California San Francisco and Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement St, 111N, San Francisco, CA 94121, USA;

    Department of Medicine, University of California San Francisco and Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement St, 111N, San Francisco, CA 94121, USA;

    Department of Medicine, University of California San Francisco and Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement St, 111N, San Francisco, CA 94121, USA;

    Department of Medicine, University of California San Francisco and Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement St, 111N, San Francisco, CA 94121, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Insulin-like growth factor 1 receptor; Osteoblasts; Unloading; Reloading; Periosteal bone formation;

    机译：胰岛素样生长因子1受体;成骨细胞;卸货;重新加载;骨膜骨形成;

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