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Predictors of immune function in space flight

机译：太空飞行中免疫功能的预测因子

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Of all of the environmental conditions of space flight that might have an adverse effect upon human immunity and the incidence of infection, space radiation stands out as the single-most important threat. As important as this would be on humans engaged in long and deep space flight, it obviously is not possible to plan Earth-bound radiation and infection studies in humans. Therefore, we propose to develop a murine model that could predict the adverse effects of space flight radiation and reactivation of latent virus infection for humans. Recent observations on the effects of gamma and latent virus infection demonstrate latent virus reactivation and loss of T cell mediated immune responses in a murine model. We conclude that using this small animal method of quantitating the amounts of radiation and latent virus infection and resulting alterations in immune responses, it may be possible to predict the degree of immunosuppression in interplanetary space travel for humans. Moreover, this model could be extended to include other space flight conditions, such as microgravity, sleep deprivation, and isolation, to obtain a more complete assessment of space flight risks for humans.
机译：在所有可能对人体免疫力和感染发生率产生不利影响的太空飞行环境条件中，太空辐射是最重要的单一威胁。尽管这对从事长距离和深空飞行的人类至关重要，但显然不可能计划对人类的地球辐射和感染研究。因此，我们建议开发一种鼠模型，该模型可以预测太空飞行辐射和对人类潜伏病毒感染的再激活的不利影响。对伽玛和潜伏病毒感染的最新观察表明，在鼠模型中潜伏病毒重新激活和T细胞介导的免疫反应丧失。我们得出的结论是，使用这种定量辐射和潜伏病毒感染的数量以及由此导致的免疫应答变化的小动物方法，可以预测人类在行星际太空旅行中的免疫抑制程度。此外，该模型可以扩展到包括其他空间飞行条件，例如微重力，睡眠剥夺和隔离，以获得对人类空间飞行风险的更完整评估。

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