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首页> 外文期刊>Acta astronautica >Both sustained orthostasis and inverse-orthostasis may elicit hypertension in conscious rat
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Both sustained orthostasis and inverse-orthostasis may elicit hypertension in conscious rat

机译：持续直立性和反位性幻觉均可导致清醒大鼠高血压

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摘要

The organism is exposed to diverse orthostatic stimuli, which can induce several acute and chronic adaptive responses. In this study, we investigated hemodynamic responses elicited by short-term and intermediate-term various orthostatic stimuli, using normotensive and hypertensive rat models. Arterial blood pressure and heart rate were measured by telemetry. Hypertension was induced by NO-synthase blockade. Effect of orthostatic and inverse-orthostatic body positions were examined in 45° head-up (HUT) or head-down tilt (HDT), either for 5 min duration repeated 3 times each with a 5-min pause "R", or as sustained tilting for 120 min "S". Data are given as mean ± SEM. In normotensives, horizontal control blood pressure was R115.4 ± 1.4/S113.7 ± 1.6 mmHg and heart rate was R386.4 ± 7.0/S377.9 ± 8.8 BPM. HUT changed blood pressure by R < ±1 (ns)/S4.6 mmHg (p < 0.05). HDT resulted in augmented blood pressure increase by R6.2 (p < 0.05)/S14.4 mmHg (p < 0.05). In NO-deprived hypertension, horizontal control hemodynamic parameters were R138.4±2.6/S140.3 ± 2.7 mmHg and R342.1 ± 12.0/S346.0 ± 8.3 BPM, respectively. HUT and HDT changed blood pressure further by R < ± 1 (ns)/S5.6 mmHg (p < 0.05) and by R8.9 (p < 0.05)/S14.4 mmHg (p < 0.05), respectively. Heart rate changed only slightly or non-specifically. These data demonstrate that both normotensive and hypertensive conscious rats restricted from longitudinal locomotion respond to sustained orthostasis or inverse-orthostasis related gravitational stimuli with moderate or augmented hypertension, respectively.
机译：该生物体暴露于多种直立性刺激下，这些刺激可引起多种急性和慢性适应性反应。在这项研究中，我们使用血压正常和高血压的大鼠模型调查了短期和中期各种体位性刺激引起的血液动力学反应。通过遥测测量动脉血压和心率。高血压是由一氧化氮合酶阻断引起的。在45°抬头（HUT）或抬头向下倾斜（HDT）的状态下检查体位和体位倒置的影响，持续5分钟，重复3次，每次5分钟，停顿“ R”，或持续倾斜120分钟“ S”。数据以平均值±SEM给出。在血压正常的人中，水平控制血压为R115.4±1.4 / S113.7±1.6 mmHg，心率为R386.4±7.0 / S377.9±8.8 BPM。 HUT将血压改变R <±1（ns）/S4.6 mmHg（p <0.05）。 HDT导致血压升高增加R6.2（p <0.05）/S14.4 mmHg（p <0.05）。在NO剥夺性高血压中，水平对照血流动力学参数分别为R138.4±2.6 / S140.3±2.7 mmHg和R342.1±12.0 / S346.0±8.3 BPM。 HUT和HDT分别使血压分别降低R <±1（ns）/S5.6 mmHg（p <0.05）和R8.9（p <0.05）/S14.4 mmHg（p <0.05）。心率仅轻微或非特定地变化。这些数据表明，受纵向运动限制的血压正常和高血压的清醒大鼠分别对持续性正定性或反反流幻觉相关的重力刺激产生中度或增强性高血压。

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