Characteristics of blood proteome changes in hemorrhagic syndrome after head-up tilt test during 21-day Dry Immersion

Pastushkova Lyudmila Ch; Goncharova Anna G.; Kashirina Daria N.; Goncharov Igor N.; Rukavishnikov Ilya V; Brzhozovskiy Alexander G.; Kononikhin Alexey S.; Koloteva Milena I; Tomilovskaya Elena S.; Nikolaev Evgeny N.; Larina Irina M.

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Characteristics of blood proteome changes in hemorrhagic syndrome after head-up tilt test during 21-day Dry Immersion

机译：21天干燥浸没后抬头倾斜试验后出血综合征血液蛋白质蛋白质蛋白质变化的特征

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The effect of the rapid redistribution of blood during head-up tilt tests in 21-day Dry Immersion suddenly became relevant in connection with the occurrence of mild hemorrhagic syndrome in the study participants. It became necessary to analyze the processes of occurrence of hemorrhagic syndrome as orthostatic and congestive purpura. The aim of this work was to study the features of the proteomic response of the human body to the rapid redistribution of blood during head-up tilt tests during 21-day immersion, which led to stagnant and orthostatic purpura. According to the results of examination of 10 healthy male volunteers aged 23-34 years after head-up tilt tests, pitting edema and local petechial hemorrhages in the soft tissues of the legs and feet were observed. Proteomic analysis of the samples was carried out by high performance liquid chromatography with tandem mass spectrometry. For bioinformatic analysis, the software packages Perseus, ANDSystem were used. From reliably different (p-value 0.05) proteins, proteins directly related to injury and changes in vascular permeability were determined. Changes in the levels of plasminogen, fibronectin, other factors of coagulation and fibrinolysis, activation of the complement system, changes in the coagulation cascade and concentrations of plasminogen and its activators (kallikrein, etc.), increased content of fibrinolysis products were revealed. A panel of proteins indicating changes in plasmin-antiplasmin, fibrinogen-soluble fibrin-monomeric complexes and other systems is identified. The obtained data are of scientific and practical interest in the direction of stratification of the risk of secondary hemosiderosis and evaluation of new treatment methods aimed at reducing reperfusion damage to soft tissues and parenchymal organs.

机译：在21天干燥浸没期间，血液快速再分布的血液中血液的效果突然与研究参与者中的轻度出血综合征的发生相关。分析出血性综合征的发生过程是必要的，作为原位和充血性紫癜。这项工作的目的是研究人体蛋白质组学响应的特征，以在21天浸没期间抬起倾斜试验期间血液快速再分布的特征，这导致了滞留性和直向性紫癜。根据抬头倾斜试验后23-34岁的10岁健康男性志愿者的检查结果，观察到腿部和脚的软组织中的水肿和局部工厂出血。样品的蛋白质组学分析通过具有串联质谱法的高效液相色谱法进行。对于生物信息分析，使用软件包Perseus，Andsystem。从可靠地不同的（p值<0.05）蛋白质，确定与损伤直接相关的蛋白质和血管渗透性的变化。纤溶酶原，纤连蛋白，凝血和纤维蛋白溶解等因素的水平的变化，互补系统的激活，凝血级联的变化及纤溶酶原的浓度及其活化剂（Kallikrein等），揭示了纤维蛋白溶解产物的增加。鉴定了一种蛋白质面板，其鉴定了抗纤溶酶 - 抗纤维蛋白，纤维蛋白原纤维蛋白 - 单体复合物和其他系统的变化。所获得的数据对次要血液探伤风险的分层方向具有科学和实际的兴趣，以及对旨在降低软组织和实质器官的再灌注损伤的新治疗方法的评估。

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来源
《Acta astronautica》 |2021年第12期|158-165|共8页
作者
Pastushkova Lyudmila Ch; Goncharova Anna G.; Kashirina Daria N.; Goncharov Igor N.; Rukavishnikov Ilya V; Brzhozovskiy Alexander G.; Kononikhin Alexey S.; Koloteva Milena I; Tomilovskaya Elena S.; Nikolaev Evgeny N.; Larina Irina M.;
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作者单位

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia;

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia;

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia;

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia;

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia;

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia|Skolkovo Inst Sci & Technol Bolshoy Blvd 30 Bld 1 Moscow 121205 Russia;

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia|Skolkovo Inst Sci & Technol Bolshoy Blvd 30 Bld 1 Moscow 121205 Russia;

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia;

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia;

Skolkovo Inst Sci & Technol Bolshoy Blvd 30 Bld 1 Moscow 121205 Russia;

SSC RF Inst Biomed Problems RAS Khoroshevskoe Shosse 76A Moscow 123007 Russia;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类
关键词
Blood proteome; Petechiae; Hemorrhagic syndrome; Dry immersion; Head-up tilt test;

机译：血液蛋白质;Petechiae;出血综合征;干浸;抬头倾斜试验;

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2. Twenty-four-hour blood pressure profile and blood pressure responses to head-up tilt tests in Parkinson's disease and multiple system atrophy. [J] . Plaschke M, Trenkwalder P, Dahlheim H, Journal of hypertension . 1998,第10期

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Characteristics of blood proteome changes in hemorrhagic syndrome after head-up tilt test during 21-day Dry Immersion

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