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Tracheobronchial and alveolar dose of submicrometer particles for different population age groups in Italy

机译:意大利不同年龄组的气管支气管和肺泡亚微米颗粒剂量

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Exposure to ultrafine particles (diameter less than 100 nm) is an important topic in epidemiological and toxicological studies. This study used the average particle number size distribution data obtained from our measurement survey in major microenvironments, together with the people activity pattern data obtained from the Italian Human Activity Pattern Survey to estimate the tracheobronchial and alveolar dose of submicrometer particles for different population age groups in Italy. We developed a numerical methodology based on Monte Carlo method, in order to estimate the best combination from a probabilistic point of view. More than 106 different cases were analyzed according to a purpose built sub-routine and our results showed that the daily alveolar particle number and surface area deposited for all of the age groups considered was equal to 1.5 x 1011 particles and 2.5 x 1015 um2, respectively, varying slightly for males and females living in Northern or Southern Italy. In terms of tracheobronchial deposition, the corresponding values for daily particle number and surface area for all age groups was equal to 6.5 x 1010 particles and 9.9 x 1014 um2, respectively. Overall, the highest contributions were found to come from indoor cooking (female), working time (male) and transportation (i.e. traffic derived particles) (children).
机译:暴露于超细颗粒(直径小于100 nm)是流行病学和毒理学研究的重要课题。这项研究使用了从我们在主要微环境的测量调查中获得的平均粒径分布数据,以及从意大利人类活动模式调查中获得的人员活动模式数据,来估算不同年龄段人群中亚微米级颗粒的气管支气管和肺泡剂量。意大利。为了从概率的角度估计最佳组合,我们开发了一种基于蒙特卡洛方法的数值方法。根据专门构建的子程序分析了106多个不同的病例,我们的结果表明,在考虑的所有年龄组中,每天的肺泡颗粒数量和表面积分别等于1.5 x 1011颗粒和2.5 x 1015 um2。 ,对于生活在意大利北部或南部的男性和女性而言,略有不同。就气管支气管沉积而言,所有年龄组的每日颗粒数和表面积的相应值分别等于6.5 x 1010颗粒和9.9 x 1014 um2。总体而言,发现贡献最大的是室内烹饪(女性),工作时间(男性)和交通(即交通产生的颗粒)(儿童)。

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