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Modelling columnarity of pyramidal cells in the human cerebral cortex

机译:人脑皮层中金字塔细胞的柱状性

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For modelling the location of pyramidal cells in the human cerebral cortex, we suggest a hierarchical point process in R3 that exhibits anisotropy in the form of cylinders extending along the z-axis. The model consists first of a generalised shot noise Cox process for the xy-coordinates, providing cylindrical clusters, and next of a Markov random field model for the z-coordinates conditioned on the xy-coordinates, providing either repulsion, aggregation or both within specified areas of interaction. Several cases of these hierarchical point processes are fitted to two pyramidal cell data sets, and of these a final model allowing for both repulsion and attraction between the points seem adequate. We discuss how the final model relates to the so-called minicolumn hypothesis in neuroscience.
机译:为了对人类脑皮质中的金字塔细胞的位置进行建模,我们建议R3中的分层过程,其沿Z轴延伸的圆柱体形式表现出各向异性。 第一模型首先由XY坐标提供XY坐标的广义射击噪声COX过程,以及用于在XY坐标上调节的Z坐标的Markov随机字段模型的下一个,提供排斥,聚合或在指定内 互动领域。 这些分层点过程的几例适合两个金字塔型细胞数据集,并且这些最终模型允许在点之间的排斥和吸引力似乎足够。 我们讨论最终模型如何涉及神经科学中所谓的Minicolumn假设。

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