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首页> 外文期刊>Behavior Genetics >MMPI Vulnerability Indicators for Schizophrenia and Attention Deficit Disorder: UCLA Family Study of Biological Parents of Offspring with Childhood-Onset Schizophrenia or ADHD
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MMPI Vulnerability Indicators for Schizophrenia and Attention Deficit Disorder: UCLA Family Study of Biological Parents of Offspring with Childhood-Onset Schizophrenia or ADHD

机译：MMPI精神分裂症和注意缺陷障碍的易感性指标：UCLA家庭研究的儿童期精神分裂症或ADHD后代的生物学父母

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Minnesota Multiphasic Personality Inventory (MMPI) scores were examined for 50 parents of children with an onset of schizophrenia prior to 14 years of age, 153 parents of children with attention deficit hyperactivity disorder (ADHD), and 168 parents of community comparison children. The parents were participants in the UCLA Family Study. The mean scores on all standard MMPI scales were within normal limits for all three groups of participants. Parents of schizophrenia probands were significantly higher on scale Sc than parents of community comparison children. Previous research has shown that scale Sc may be associated with a genetic liability to developing schizophrenia. Thus, scale Sc shows promise as an indicator of a heightened risk for the development of schizophrenia. The parents of the ADHD probands were significantly higher on standard clinical scale Pd than community comparison parents. Mothers of both schizophrenia and ADHD probands shared some personality indicators of stress reactivity. Although this study, like all non-adoptee family studies, cannot disentangle genetic effects on the development of these personality characteristics from environmental effects, we speculate that the emotional distress resulting in higher levels of the MMPI characteristics seen in the patients’ mothers reflects the impact of raising a psychiatrically ill offspring.
机译：对明尼苏达州多相性人格量表（MMPI）得分进行了检查，调查对象是50位14岁之前发作的精神分裂症儿童的父母，153位患有注意力缺陷多动障碍（ADHD）的儿童父母和168位社区比较儿童的父母。父母是加州大学洛杉矶分校家庭研究的参与者。所有三组参与者的所有标准MMPI量表的平均分数均在正常范围内。精神分裂症先证者的父母在Sc量表上显着高于社区比较儿童的父母。先前的研究表明，Sc量表可能与精神分裂症的遗传遗传因素有关。因此，量表Sc显示出有希望作为精神分裂症发展风险增加的指标。在标准临床规模Pd上，ADHD先证者的父母明显高于社区比较父母。精神分裂症和ADHD先证者的母亲共享一些压力反应性的个性指标。尽管该研究与所有非收养家庭研究一样，无法将遗传效应与这些人格特征的发展与环境效应分离开来，但我们推测，情绪困扰导致患者母亲中MMPI特征水平较高，反映出这种影响抚养患有精神病的后代。

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