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首页> 外文期刊>Biochemical Genetics >Prion Protein Polymorphisms and Estimation of Risk of Scrapie in East Asian Sheep
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Prion Protein Polymorphisms and Estimation of Risk of Scrapie in East Asian Sheep

机译：东亚绵羊的on病毒蛋白多态性和of割风险的估计

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摘要

Allele and genotype frequency distributions of prion protein (PrP) polymorphisms at three codons, 136, 154, and 171, in East Asian sheep were determined by PCR–RFLP analysis using 553 animals from nine local breeds of the northern group and four local breeds of the southern group. Based on the genotype distribution, the risk score for scrapie was estimated. Among the local breeds, ARQ appeared predominantly (0.7701–1), followed by ARH and ARR. From such a biased allele distribution, it was difficult to ascertain the prevalent genetic relationships. A marked difference in allele frequencies between the northern and southern groups was seen (P < 0.0001). The East Asian sheep had ARQ at the highest frequency (0.8834); in European sheep it was 0.5317. According to an assessment of scrapie risk in the PrP genotype classes, the predominant ARQ/ARQ in East Asian sheep corresponded to the risk score of R4. This finding suggests that East Asian sheep have a high level of genetic susceptibility to scrapie. Keywords Prion protein - RFLP - Local sheep breed - Scrapie - Asia
机译：通过PCR-RFLP分析，使用北组9个地方品种和4个地方品种的553只动物，通过PCR-RFLP分析确定了东亚绵羊中3个密码子的ion病毒蛋白（PrP）多态性的等位基因和基因型频率分布。南方集团。根据基因型分布，估计瘙痒病的风险评分。在当地品种中，ARQ占主要地位（0.7701-1），其次是ARH和ARR。从这样的等位基因分布偏倚，很难确定普遍的遗传关系。北部和南部组之间的等位基因频率存在明显差异（P <0.0001）。东亚绵羊的ARQ频率最高（0.8834）。在欧洲绵羊中为0.5317。根据对PrP基因型类别中瘙痒病风险的评估，东亚绵羊中主要的ARQ / ARQ与R4风险评分相对应。这一发现表明东亚绵羊对瘙痒病的遗传易感性很高。 Pri蛋白-RFLP-当地绵羊品种-Scrapie-亚洲

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