...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochemical Genetics >Stearoyl-CoA Desaturase (SCD) Gene Polymorphism in Goat Breeds
【24h】

Stearoyl-CoA Desaturase (SCD) Gene Polymorphism in Goat Breeds

机译：山羊品种中的硬脂酰辅酶A去饱和酶（SCD）基因多态性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There is evidence that stearoyl-CoA desaturase (SCD) is a key enzyme for lipid metabolism. Changes in enzyme activity that depends on SCD gene polymorphism and regulation could cause variations of fatty acid composition of meat and milk. We investigated genetic variability in caprine SCD, analyzing 335 animals belonging to three goat breeds by single-strand conformation polymorphism and DNA sequencing. Six single nucleotide polymorphism were identified, in intron 3 (585T→A and 601A→G; Ref. AF422168), intron 4 (719T→A; AF422169), and exon 6 (690 A→G, 718 C→G, and 802 A→C; AF422171). The less polymorphic SNP 601A→G displayed variability only in Xuhuai and Boer breeds. Across breeds, the average frequency for the least frequent alleles ranged from 0.1158 to 0.2532. The three SNPs in exon 6 resulted in variations of amino acids 313 tyr → cys, 322 phe → leu, and 350 arg → ser. The allelic distribution in exon 6 of Xuhuai was significantly different from Boer and Haimen.
机译：有证据表明硬脂酰辅酶A去饱和酶（SCD）是脂质代谢的关键酶。取决于SCD基因多态性和调控的酶活性变化可能导致肉和牛奶中脂肪酸组成的变化。我们调查了山羊SCD中的遗传变异性，通过单链构象多态性和DNA测序分析了335个属于三个山羊品种的动物。在内含子3（585T→A和601A→G; Ref。AF422168），内含子4（719T→A; AF422169）和外显子6（690A→G，718 C→G和802）中鉴定出六个单核苷酸多态性A→C； AF422171）。较少多态的SNP 601A→G仅在徐淮和波尔品种中表现出变异性。在各个品种中，最不常见的等位基因的平均频率范围为0.1158至0.2532。外显子6中的三个SNP导致氨基酸313 tyr→cys，322 phe→leu和350 arg→ser的变异。徐淮外显子6的等位基因分布与波尔和海门明显不同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号