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首页> 外文期刊>Biochemical Genetics >FAS and FAS Ligand Polymorphisms in the Promoter Regions and Risk of Gastric Cancer in Southern China
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FAS and FAS Ligand Polymorphisms in the Promoter Regions and Risk of Gastric Cancer in Southern China

机译：中国南方地区启动子区域的FAS和FAS配体多态性与胃癌的风险

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摘要

The FAS and FAS ligand (FASLG) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis. Functional promoter polymorphisms of the FAS and FASLG genes can alter transcriptional activities and thus alter risk of cancer. We hypothesized that the FAS −1377G>A, FAS −670A>G, and FASLG −844T>C polymorphisms in the promoter regions are associated with risk of gastric cancer. In a population-based case-control study of 332 gastric cancer cases and 324 controls, we genotyped these three polymorphisms and evaluated their association with risk of gastric cancer. We found that the FAS and FASL genotypes and the FAS haplotypes had no significant associations with risk of gastric cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of gastric cancer. The FAS and FASLG polymorphisms may not contribute to risk of gastric cancer in the southern Chinese population. Keywords FAS - FAS ligand - Gastric cancer - Susceptibility - Molecular epidemiology Meilin Wang, Dongmei Wu, and Ming Tan have contributed equally to this work.
机译：FAS和FAS配体（FASLG）系统在调节凋亡细胞死亡中起关键作用，并且该信号通路的破坏已显示参与肿瘤发生。 FAS和FASLG基因的功能性启动子多态性可以改变转录活性，从而改变患癌症的风险。我们假设启动子区域中的FAS -1377G> A，FAS -670A> G和FASLG -844T> C多态性与胃癌的风险相关。在基于人群的332例胃癌病例和324例对照病例对照研究中，我们对这三个多态性进行了基因分型，并评估了它们与胃癌风险的相关性。我们发现FAS和FASL基因型和FAS单倍型与胃癌的风险没有显着相关性。此外，在胃癌的发展过程中，FAS和FASL多态性之间没有显着的相互作用。 FAS和FASLG多态性可能不会增加中国南方人群患胃癌的风险。关键词FAS-FAS配体-胃癌-易感性-分子流行病学王梅林，吴冬梅和谭明为这项工作做出了同样的贡献。

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