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Extensive Diversity of the ADRB3 Gene in Chinese Sheep Identified by PCR-SSCP

机译：PCR-SSCP鉴定中国绵羊ADRB3基因的广泛多样性

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摘要

The β3-adrenergic receptor (ADRB3) is the main mediator of the lipolytic and thermogenic effects of high catecholamine concentrations. Polymorphism in the ovine ADRB3 gene has been reported to be associated with birth weight, growth rate, carcass composition, and cold survival. Eight alleles have been identified in New Zealand sheep, but to date, breeds from other countries have not been studied in detail. In this study, we employed PCR-SSCP to detect ADRB3 polymorphism in the Hu, Tan, small-tailed Han, and Tibet breeds of Chinese sheep. Thirteen SSCP patterns were observed, including the eight previously reported and five new patterns. The newly identified SSCP patterns represent five novel sequences, increasing the reported number of alleles of ADRB3 from 8 to 13. In these Chinese sheep, the most common allele was the previously reported allele C (49.0%); the A allele was the next most common (22.0%). These results suggest that Chinese sheep have more diversity in ADRB3 than New Zealand sheep and therefore have possibly been selected either naturally or via breeding for different traits. Keywords β3-Adrenergic receptor (ADRB3) gene - Variation - PCR-SSCP - Chinese sheep
机译：β 3 -肾上腺素能受体（ADRB3）是高儿茶酚胺浓度的脂解作用和生热作用的主要介质。据报道，绵羊ADRB3基因的多态性与出生体重，生长速度，car体组成和寒冷生存有关。在新西兰绵羊中已经鉴定出八个等位基因，但是迄今为止，尚未对来自其他国家的品种进行详细研究。在这项研究中，我们使用PCR-SSCP检测中国绵羊的Hu，Tan，小尾寒汉和西藏品种的ADRB3多态性。观察到13种SSCP模式，包括先前报告的8种和5种新模式。新近鉴定的SSCP模式代表了五个新序列，使报道的ADRB3等位基因数量从8个增加到13个。在这些中国绵羊中，最常见的等位基因是先前报道的等位基因C（占49.0％）。位居第二的是等位基因（22.0％）。这些结果表明，中国羊在ADRB3中的多样性要比新西兰羊更多，因此，有可能是自然选择或通过育种选择不同性状的。关键词β 3 -肾上腺素能受体（ADRB3）基因-变异-PCR-SSCP-中国绵羊

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