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Lack of Association of the HbE Variant with Protection from Cerebral Malaria in Thailand

机译:在泰国缺乏HbE变异与保护免受脑型疟疾的联系

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摘要

Hemoglobin E (HbE; β26Glu → Lys) is the most common variant of the β-globin gene in Southeast Asia; it has been suggested that it confers resistance against Plasmodium falciparum malaria. In this study 306 adult patients with P. falciparum malaria (198 mild and 108 cerebral malaria patients) living in northwest Thailand were investigated to examine whether the HbE variant is associated with protection from cerebral malaria. Our results revealed that the sample allele frequency of HbE was not significantly different between mild (7.3%) and cerebral malaria (7.4%) patients. Thus, the HbA/HbE polymorphism would not be a major genetic factor influencing the onset of cerebral malaria in Thailand.
机译:血红蛋白E(HbE; β 26Glu→Lys)是东南亚地区最常见的β-球蛋白基因变体。已经表明它赋予对恶性疟原虫疟疾的抗性。在这项研究中,调查了居住在泰国西北部的306例恶性疟原虫疟疾成年患者(198例轻度和108例脑疟疾患者),以检查HbE变异体是否与对脑疟疾的保护有关。我们的结果表明,轻度(7.3%)和脑疟疾(7.4%)患者的HbE样本等位基因频率无显着差异。因此,HbA / HbE多态性不会成为影响泰国脑疟疾发作的主要遗传因素。

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