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首页> 外文期刊>Biochemical Genetics >Variation of 423G>T in the Agouti Gene Exon 4 in Indigenous Chinese Goat Breeds
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Variation of 423G>T in the Agouti Gene Exon 4 in Indigenous Chinese Goat Breeds

机译：中国本土山羊品种Agouti基因第4外显子的423G> T变异

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摘要

The Agouti gene plays an important role in pigment synthesis in domestic animals. A transversion of 423G>T recognized by BanII was found after a fragment (178 bp) of the goat Agouti gene exon 4 was amplified and sequenced. To investigate its genetic effect and diversity, 677 individuals from 12 indigenous Chinese goat breeds and one imported goat breed from South Africa (Boer goat) were analyzed by PCR-RFLP. Two alleles, T and G, and three genotypes, TT, TG, and GG, were detected. Allele T had a higher frequency in most goat breeds and, combined with the coat color phenotype, is believed to be responsible for the black phenotype or to be linked with the causative site in the goat. The results also indicate that the 423G>T transversion showed lower genetic diversity in goat breeds with black coat color in China. Genetic differentiation among the 13 goat populations was 0.2023. The clustering of populations based on the 423G>T site was basically consistent with the variation of coat color.
机译：Agouti基因在家畜的色素合成中起重要作用。在山羊Agouti基因外显子4的一个片段（178 bp）被扩增并测序后，发现了被BanII识别的423G> T的转化。为了研究其遗传效应和多样性，通过PCR-RFLP分析了来自12个中国本土山羊品种和1个从南非进口的山羊品种（布尔山羊）的677个个体。检测到两个等位基因T和G，以及三个基因型TT，TG和GG。在大多数山羊品种中，等位基因T的发生频率较高，并且与外皮颜色表型结合被认为是造成黑色表型的原因或与山羊中的致病位点有关。结果还表明，在中国，黑毛色山羊品种的423G> T颠倒显示出较低的遗传多样性。 13个山羊种群之间的遗传分化为0.2023。基于423G> T位点的种群聚类与外衣颜色的变化基本一致。

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