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首页> 外文期刊>Biochemical Genetics >Biochemical, ECF18R, and RYR1 Gene Polymorphisms and Their Associations with Osteochondral Diseases and Production Traits in Pigs
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Biochemical, ECF18R, and RYR1 Gene Polymorphisms and Their Associations with Osteochondral Diseases and Production Traits in Pigs

机译：生化，ECF18R和RYR1基因多态性及其与猪骨软骨疾病和生产特性的关系

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摘要

This study reports the association of five blood types, three enzymes, two proteins, Escherichia coli F18 receptor gene (ECF18R), and the Ryanodin receptor (RYR1) gene with six production traits, four meat quality traits, and two osteochondral diseases in Swiss pig populations. Data on on-farm traits (daily weight gain, percent premium cuts, and backfat) and on station-tested traits (daily weight gain, feed conversion ratio, meat quality, and osteochondral lesions) were available on 3,918 and 303 animals, respectively. A mixed linear model with allele substitution effects was used for each trait by marker analysis (144 analyses). Significant marker-trait associations and allele substitution effects are presented. In general, heritability estimates for production and meat quality traits were higher than those for osteochondral lesions. Blood types lack significant associations with many traits except H and S types. Enzymes (mainly, glucose phosphate isomerase) and protein polymorphisms show significant associations with daily weight gain, premium cuts, and backfat as well as osteochondral lesions. The RYR and ECF18R genes significantly affected all growth, production, and lean meat content traits and osteochondral lesions; RYR also affected pH values. This study reports many novel marker-trait associations, particularly between the incidence of osteochondral lesions and polymorphisms at glucose phosphate isomerase, 6-phosphogluconate dehydrogenase, postalbumin 1A, RYR, and ECF18R loci. These results should be useful in selection and for further functional genomics and proteomics investigations.
机译：这项研究报告了瑞士猪的五种血液类型，三种酶，两种蛋白质，大肠杆菌F18受体基因（ECF18R）和Ryanodin受体（RYR1）基因与六种生产性状，四种肉质性状和两种骨软骨病的关联人口。分别有3,918只和303只动物提供了农场性状（日增重，减脂百分比和背脂）和经过站址测试的性状（日增重，饲料转化率，肉质和软骨损伤）的数据。通过标记分析（144次分析），将具有等位基因替代作用的混合线性模型用于每个性状。提出了重要的标记-性状关联和等位基因替代作用。通常，生产和肉质性状的遗传力估计值高于骨软骨病变的遗传力估计值。血型除了H型和S型外，与其他许多特征缺乏明显的联系。酶（主要是葡萄糖磷酸异构酶）和蛋白质多态性与日增重，优质减脂，背脂以及骨软骨病变密切相关。 RYR和ECF18R基因显着影响所有生长，生产，瘦肉含量性状和骨软骨病。 RYR也影响pH值。这项研究报告了许多新颖的标志物-性状关联，特别是在骨软骨病变的发生率与葡萄糖磷酸异构酶，6-磷酸葡萄糖酸脱氢酶，白蛋白后蛋白1A，RYR和ECF18R位点的多态性之间。这些结果在选择以及进一步的功能基因组学和蛋白质组学研究中应该是有用的。

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