NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1

Raman Parkesh Matthew Fountain and Matthew D. Disney

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NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1

机译：r（CCGCUGCGG）2的NMR光谱和分子动力学模拟揭示了在1型强直性营养不良中发现的动态UU内部环。

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The NMR structure of an RNA with a copy ofnthe 50nCUG/30nGUC motif found in the triplet repeatingndisorder myotonic dystrophy type 1 (DM1) is disclosed.nThe lowest energy conformation of the UU pair is a single-nhydrogen bond structure; however, theUU protons undergonexchange indicating structural dynamics.Molecular dynam-nics simulations show that the single hydrogen bond struc-nture is the most populated one but the UU pair inter-nconverts among zero, one, and two hydrogen bond pairs.nThese studies have implications for the recognition of thenDM1 RNA by small molecules and proteins

机译：揭示了在三重重复1型强直性肌营养不良症类型1（DM1）中发现的具有50nCUG / 30nGUC基序拷贝的RNA的NMR结构。nUU对的最低能量构象是单氢键结构；分子动力学模拟表明，单个氢键结构是最密集的一个，但UU对在零，一和两个氢键对之间相互转换。n这些研究具有重要意义。通过小分子和蛋白质识别thenDM1 RNA

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《Biochemistry》 |2011年第5期|p.599-601|共3页
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Raman Parkesh Matthew Fountain and Matthew D. Disney;
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‡The Kellogg School of Science and Technology and Department of Chemistry, The Scripps Research Institute, Scripps Florida,130 Scripps Way #3A1, Jupiter, Florida 33458, United States, and §The Department of Chemistry,The State University of New York at Fredonia, 218 Houghton Hall, Fredonia, New York 14063, United States;

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1. NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)(2) Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 [J] . Parkesh R, Fountain M, Disney MD Biochemistry . 2011,第5期

机译：r（CCGCUGCGG）（2）的NMR光谱和分子动力学模拟揭示了在1型强直性营养不良中发现的动态UU内部环
2. Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 x 1 Nucleotide UU Internal Loop Conformations [J] . Amit Kumar, HaJeung Park, Pengfei Fang, Biochemistry . 2011,第45期

机译：肌强直性营养不良1型RNA晶体结构显示异质1 x 1核苷酸UU内部环构象
3. Molecular dynamics correctly models the unusual major conformation of the GAGU RNA internal loop and with NMR reveals an unusual minor conformation [J] . Spasic Aleksandar, Kennedy Scott D., Needham Laura, RNA . 2018,第5期

机译：分子动力学正确模拟GAGU RNA内环的不寻常的主要构象，并且NMR揭示了不寻常的轻微构象
4. Solvation of Carbohydrates in 1,3-Dialkylimidazolium Ionic Liquids: Insights from Multinuclear NMR Spectroscopy and Molecular Dynamics Simulations [C] . Igor D. Petrik, Richard C. Remsing, Zhiwei Liu, Ionic liquids : From knowledge to application . 2009

机译：1,3-二烷基咪唑鎓离子液体中的碳水化合物溶剂化：多核NMR光谱和分子动力学模拟的见解
5. Protein Dynamics, Loop Motions and Protein-Protein Interactions Combining Nuclear Magnetic Resonance (NMR) Spectroscopy with Molecular Dynamics (MD) Simulations. [D] . Gu, Yina. 2016

机译：结合核磁共振（NMR）光谱和分子动力学（MD）模拟的蛋白质动力学，循环运动和蛋白质相互作用。
6. NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 [O] . Raman Parkesh, Matthew Fountain, Matthew D. Disney -1

机译：NmR光谱和r（CCGCUGCGG）2的分子动力学模拟显示在强直性肌营养不良1型实测值动态UU内循环
7. NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 [O] . Raman Parkesh, Matthew Fountain, Matthew D. Disney 2011

机译：R（CCGCugcgg）2中发现的NMR光谱和分子动力学模拟肌营养不良型1型中的动态UU内环

NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1

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